지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 48 - 56 (9page)
이용수
초록· 키워드
오류제보하기
Chronic ultraviolet (UV) exposure is the major cause of photoaging that causes skin wrinkling, roughness, dryness, laxity, and pigmentation. Recently, increasing efforts are being made to understand the relationship between foods and skin health. Ginsenosides are present in ginseng (Ginseng Radix Rubra) extract, and are known to have biomedical properties, such as, anti-oxidant and anti-inflammatory effects. In this study, we investigated whether KTNG0345 prepared from red ginseng extracts delivered orally reduces skin wrinkling and ultraviolet B (UVB)-induced wrinkle formation in hairless mouse skin. KTNG0345 was administrated orally to the mice (5 times a week) during the period of UVB-irradiation (3 times a week) for 8 weeks at three different doses of 300 ㎎/㎏, 500 ㎎/㎏ and 1000 ㎎/㎏ (w/v). UV doses were increased weekly by 1 MED (1MED = 75 mJ/㎠) up to 4 MED and then maintained at this level. After the 8-week administration period, it was found that orally administered KTNG0345 significantly inhibited UVB-induced wrinkle formation in a dose-dependent manner. Increases in skin thickness caused by UVB were prevented by KTNG0345. Moreover, it also significantly inhibited matrix metalloproteinases (MMP) -13 and MMP-9 expressional inductions by UVB. In addition, KTNG0345 was observed to prevent UVB-induced water loss of epidermis in hairless mouse skin. Our results demonstrate that orally administered KTNG0345 has anti-wrinkling effects in hairless mouse skin, and suggest that dietary red ginseng and herbal mixture may be considered a functional beauty food for preventing UVB-induced skin wrinkles.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Gilchrest,B.A / 1989 / Skin aging and photoaging: an overview / J Am Acad Dermatol 21 : 610 ~ 613
2. [학술지(정기간행물)] - Fisher,G.J / 2002 / Mechanisms of photoaging and chronolocial skin aging / Arch Dermatol 138 : 1462 ~ 1470
3. [학술지(정기간행물)] - Chung,J.H / 2003 / Photoaging in Asians / Photodermatol photoimmunol photomed 19 : 109 ~ 121
4. [학술지(정기간행물)] - Brenneisen,P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann N Y Acad Sci 973 : 31 ~ 43
5. [학술지(정기간행물)] - Chung,J.H / 2003 / Aging and photoaging / J Am Acad Dermatol 49 : 690 ~ 697
2. [학술지(정기간행물)] - Fisher,G.J / 2002 / Mechanisms of photoaging and chronolocial skin aging / Arch Dermatol 138 : 1462 ~ 1470
3. [학술지(정기간행물)] - Chung,J.H / 2003 / Photoaging in Asians / Photodermatol photoimmunol photomed 19 : 109 ~ 121
4. [학술지(정기간행물)] - Brenneisen,P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann N Y Acad Sci 973 : 31 ~ 43
5. [학술지(정기간행물)] - Chung,J.H / 2003 / Aging and photoaging / J Am Acad Dermatol 49 : 690 ~ 697
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자외선 ( UVB ) 노출 증가에 대한 피부암 위해도 예측 모델의 적용 ( Application of the Health Risk Models Estimating Skin Cancer Caused by UVB Radiation )
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UCI(KEPA) : I410-ECN-0101-2010-524-001398210