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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 201 - 213 (13page)
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초록· 키워드
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Post-thymic naive T cells constitute a key cellular arm of adaptive immunity, with a wellknown characteristic of the specificity and robustness of responses to cognate foreign antigens which is presented as a form of antigen-derived peptides bound to major histocompatibility complex (MHC) molecules by antigen-presenting cells (APCs). In a steady state, however, these cells are resting, quiescent in their activity, but must keep full ranges of functional integrity to mount rapid and robust immunity to cope with various infectious pathogens at any time and space. Such unique property of resting naive T cells is not acquired in a default manner but rather requires an active mechanism. Although our understanding of exactly how this process occurs and what factors are involved remains incomplete, a particular role of self-recognition by T cells has grown greatly in recent years. In this brief review, we discuss recent data on how the interaction of T cells with self-peptide MHC ligands regulates their functional responsiveness and propose that variable strength of selfreactivity imposes distinctly different levels of functional competence and heterogeneity.
목차
ABSTRACT
INTRODUCTION
IMPACT OF TCR RECOGNITION OF ENDOGENOUS SELFPMHCLIGANDS ON NAÏVE T CELL RESPONSIVENESS TO COGNATE FOREIGN ANTIGENS
INFLUENCE OF THE STRENGTH OF TCR SELFRECOGNITIONON THEIR ANTIGEN-SPECIFIC IMMUNE RESPONSES
REGULATORY IMPACT OF TCR SELF-RECOGNITION ON TCELL RESPONSIVENESS
CONCLUDING REMARKS
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (52)
참고문헌 신청
Jameson SC, Hogquist KA, Bevan MJ. Specificity and flexibility in thymic selection. Nature 1994;369:750-752.
Kisielow P, Miazek A. Thymic selection and tolerance. Transplant Proc 1996;28:3429-3430.
Kruisbeek AM, Zuniga-Pflucker J, Marusi?-Galesi? S, Weston MA, Tentori L, Longo DL. Thymic selection of the T-cell repertoire. Immunol Res 1988;7:318-328.
Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol 2003;21:139-176.
Klein L, Hinterberger M, Wirnsberger G, Kyewski B. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol 2009;9:833-844.
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