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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 298 - 305 (8page)
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초록· 키워드
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Stem cell-like tumor cells are reported to be the main reason for tumor recurrence and metastasis. As one of the new approaches to overcome cancer, studies are emerging to inhibit the expressions of stem cell transcriptional factors (Oct4, Sox2, Klf-4, and Lin28) in cancer cells. MicroRNAs are master genetic regulators that can control development and differentiation of stem cells. In this study using various ovarian tumors (Skov3, Ovcar3, Tov112D, Tov21G, PA-1 and Hsc832(c)T), we examined the expressions of stem cell-related transcription factors, and the biological changes in cell survival and growth by miR-126 that targets stem cell transcriptional factors. We observed that treatment of miR-126 induced the morphological changes and cell suspension in most cells. In addition, miR-126 induced gradual regression of cell division except Skov3 cells, especially significant time-dependent reduction in Tov112D, Tov21G and PA-1. When we examined the expression of stem cell transcriptional factors, Sox2 was shown to be down-regulated after miR-126. Our results demonstrate that miR-126 treatment can provide the reversible environment to regulate cell division and to induce cell death of ovarian tumors, suggesting the molecular biological clues for clinical usage.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Adachi K / 2013 / Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells / Mol Cell 52 (3) : 380 ~ 392
Ann Pietrangelo / / The outlook for ovarian cancer: prognosis, life expectancy & survival rates by stage
Becker KA / 2006 / Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase / Journal of cellular physiology 209 (3) : 883 ~ 893
Chien CS / 2015 / Lin28B/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state / Cancer Res 75 (21) : 2553 ~ 2565
Cimadamore F / 2013 / Sox2-Lin28/let-7 pathway regulates proliferation and neurogenesis in neural precursors / Proc Natl Acad Sci 110 (32) : E3017 ~ E3026
Ann Pietrangelo / / The outlook for ovarian cancer: prognosis, life expectancy & survival rates by stage
Becker KA / 2006 / Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase / Journal of cellular physiology 209 (3) : 883 ~ 893
Chien CS / 2015 / Lin28B/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state / Cancer Res 75 (21) : 2553 ~ 2565
Cimadamore F / 2013 / Sox2-Lin28/let-7 pathway regulates proliferation and neurogenesis in neural precursors / Proc Natl Acad Sci 110 (32) : E3017 ~ E3026
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