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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제1호
- 발행연도
- 2016.1
- 수록면
- 151 - 159 (9page)
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초록· 키워드
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Nanoparticles have wide-scale applications in various areas, including medicine, chemistry, electronics, and energy generation. Several physical, biological, and chemical methods have been used for synthesis of silver nanoparticles. Green synthesis of silver nanoparticles using plants provide advantages over other methods as it is easy, efficient, and eco-friendly. Nanoparticles have been extensively studied as potential antimicrobials to target pathogenic and multidrug-resistant microorganisms. Their applications recently extended to development of antivirals to inhibit viral infections. In this study, we synthesized silver nanoparticles using Cinnamomum cassia (Cinnamon) and evaluated their activity against highly pathogenic avian influenza virus subtype H7N3. The synthesized nanoparticles were characterized using UVVis absorption spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy. Cinnamon bark extract and its nanoparticles were tested against H7N3 influenza A virus in Vero cells and the viability of cells was determined by tetrazolium dye (MTT) assay. The silver nanoparticles derived from Cinnamon extract enhanced the antiviral activity and were found to be effective in both treatments, when incubated with the virus prior to infection and introduced to cells after infection. In order to establish the safety profile, Cinnamon and its corresponding nanoparticles were tested for their cytotoxic effects in Vero cells. The tested concentrations of extract and nanoparticles (up to 500 μg/ml) were found non-toxic to Vero cells. The biosynthesized nanoparticles may, hence, be a promising approach to provide treatment against influenza virus infections.
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참고문헌 (65)
참고문헌 신청
Ankamwar B / 2005 / Gold nanotriangles biologically synthesized using tamarind leaf extract and potential application in vapor sensing / Syn. React. Inorg. Met 35:19~26
Ankanna S / 2010 / Production of biogenic silver nanoparticles using Boswellia ovalifoliolata stem bark / Dig. J. Nanomater. Biostruct 5:369~372
Bae CH / 2002 / Formation of silver nanoparticles by laser ablation of a silver target in NaCl solution / Appl. Surf. Sci 197:628~634
Baram-Pinto D / 2010 / Inhibition of HSV-1 attachment, entry, and cell-to-cell Spread by functionalized multivalent gold nanoparticles / Small 6:1044~1050
Baram-Pinto D / 2009 / Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate / Bioconjug. Chem 20:1497~1502
Ankanna S / 2010 / Production of biogenic silver nanoparticles using Boswellia ovalifoliolata stem bark / Dig. J. Nanomater. Biostruct 5:369~372
Bae CH / 2002 / Formation of silver nanoparticles by laser ablation of a silver target in NaCl solution / Appl. Surf. Sci 197:628~634
Baram-Pinto D / 2010 / Inhibition of HSV-1 attachment, entry, and cell-to-cell Spread by functionalized multivalent gold nanoparticles / Small 6:1044~1050
Baram-Pinto D / 2009 / Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate / Bioconjug. Chem 20:1497~1502
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