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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제6호
- 발행연도
- 2009.1
- 수록면
- 629 - 633 (5page)
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초록· 키워드
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The present study investigated the antimetastatic
property of chitosan oligosaccharides (COS) by evaluating
motility, invasion, and the amount and activity of MMP-9
in MDA-MB-231 human breast carcinoma cells. Treatment
of MDA-MB-231 cells with increasing concentrations of
COS led to a concentration-dependent decrease in cell
migration. COS significantly inhibited the invasion of
MDA-MB-231 cells through a Matrigel-coated membrane.
The treatment of MDA-MB-231 cells with COS reduced
the amounts of secreted MMP-9. The activity and amount
of MMP-9 protein in MDA-MB-231 cells were decreased
by treatment with COS and occurred in a concentrationdependent
manner. Our data indicated that COS can
serve as a potential novel therapeutic candidate for the
treatment of metastatic breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Aye, M. M. / 2004 / Ethanol-induced in vitro invasion of breast cancer cells: The contribution of MMP-2 by fibroblasts / Int. J. Cancer 112 : 738 ~ 746
Bachmeier, B. E. / 2001 / Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity / Anticancer Res 21 : 3821 ~ 3828
Chen, J. / 2003 / Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro / Breast Cancer Res. Treat 80 : 16
Cho, Eun Jae / 2008 / Chitosan Oligosaccharides Inhibit Adipogenesis in 3T3-L1 Adipocytes / Journal of Microbiology and Biotechnology 18 (1) : 80 ~ 87
Friedel, G. / 2002 / Results of lung metastasectomy from breast cancer: Prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases / Eur.
Bachmeier, B. E. / 2001 / Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity / Anticancer Res 21 : 3821 ~ 3828
Chen, J. / 2003 / Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro / Breast Cancer Res. Treat 80 : 16
Cho, Eun Jae / 2008 / Chitosan Oligosaccharides Inhibit Adipogenesis in 3T3-L1 Adipocytes / Journal of Microbiology and Biotechnology 18 (1) : 80 ~ 87
Friedel, G. / 2002 / Results of lung metastasectomy from breast cancer: Prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases / Eur.
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