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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제9호
- 발행연도
- 2018.1
- 수록면
- 1,573 - 1,579 (7page)
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Transcriptional gene silencing is regulated by the chromatin structure, which is by various factors including histones. Saccharomyces cerevisiae contains transcriptionally silenced regions such as telomeric regions and hidden mating (HM) loci. The positively-charged amino acids on the histone H4 tail were reported to be critical for the telomeric silencing in yeast, by interacting with Dot1, a specific methyltransferase for the 79th lysine on histone H3. However, Dot1 did not affect gene silencing within HM loci, but whether the positively-charged amino acids on the H4 tail affect HM silencing has not been defined. To elucidate the function of the H4 tail on HM silencing, we created several MATa-type yeast strains bearing the substitution of arginine with alanine or lysine on the histone H4 tail and checked the sensitivity of MATatype yeast to alpha pheromone. The arginine point mutants substituted by alanine (R17A, R19A, and R23A) did not show sensitivity to alpha pheromone, but only two arginine mutants substituted by lysine (R17K and R19K) restored the sensitivity to alpha pheromone-like wild type. These data suggested that the basic property of arginine at 17th and 19th positions in the histone H4 tail is critical for maintaining HM silencing, but that of the 23rd arginine is not. Our data implicated that the positive charge of two arginine residues on the histone H4 tail is required for HM silencing in a manner independent of Dot1.
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참고문헌 (23)
참고문헌 신청
Shilatifard A / 2012 / The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis / Annu. Rev. Biochem. 81:65~95
Kornberg RD / 1999 / Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome / Cell 98:285~294
Lee JS / 2010 / The language of histone crosstalk / Cell 142:682~685
Grewal SI / 2007 / Heterochromatin revisited / Nat. Rev. Genet. 8:35~46
Nasmyth KA / 1980 / The structure of transposable yeast mating type loci / Cell 19:753~764
Kornberg RD / 1999 / Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome / Cell 98:285~294
Lee JS / 2010 / The language of histone crosstalk / Cell 142:682~685
Grewal SI / 2007 / Heterochromatin revisited / Nat. Rev. Genet. 8:35~46
Nasmyth KA / 1980 / The structure of transposable yeast mating type loci / Cell 19:753~764
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