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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 397 - 405 (9page)
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The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in both cancerous and noncancerous cells have been widely reported. This study aimed to evaluate the role of lncRNA GAS5 in heart failure caused by myocardial infarction. We reported that silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, as cell viability was increased and apoptosis rate was decreased. This phenomenon was coupled with the down-regulated expression of p53, Bax and cleaved caspase-3, as well as the up-regulated expression of CyclinD1, CDK4 and Bcl-2. At the meantime, the expression of four heart failure-related miRNAs was altered when lncRNA GAS5 was silenced (miR-21 and miR-142-5p were up-regulated; miR-30b and miR-93 were down-regulated). RNA immunoprecipitation assay results showed that lncRNA GAS5 worked as a molecular sponge for miR-142-5p. More interestingly, the protective actions of lncRNA GAS5 silence on hypoxia-stimulated cells were attenuated by miR-142-5p suppression. Besides, TP53INP1 was a target gene for miR-142-5p. Silence of lncRNA GAS5 promoted the activation of PI3K/AKT and MEK/ERK signaling pathways in a miR-142-5p-dependent manner. Collectively, this study demonstrated that silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p, functionally releasing TP53INP1 mRNA transcripts that are normally targeted by miR-142-5p.
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참고문헌 (40)
참고문헌 신청
Adams, B. D. / 2017 / Targeting noncoding RNAs in disease / J. Clin. Invest 127:761~771
Ambrosy, A. P. / 2014 / The global health and economic burden of hospitalizations for heart failure : lessons learned from hospitalized heart failure registries / J. Am. Coll. Cardiol 63:1123~1133
Bader, A. G. / 2005 / Oncogenic PI3K deregulates transcription and translation / Nat. Rev. Cancer 5:921~929
Ballantyne, M. D. / 2016 / lncRNA/MicroRNA interactions in the vasculature / Clin. Pharmacol. Ther 99:494~501
Cao, M. X. / 2017 / The crosstalk between lncRNA and microRNA in cancer metastasis : orchestrating the epithelial-mesenchymal plasticity / Oncotarget 8:12472~12483
Ambrosy, A. P. / 2014 / The global health and economic burden of hospitalizations for heart failure : lessons learned from hospitalized heart failure registries / J. Am. Coll. Cardiol 63:1123~1133
Bader, A. G. / 2005 / Oncogenic PI3K deregulates transcription and translation / Nat. Rev. Cancer 5:921~929
Ballantyne, M. D. / 2016 / lncRNA/MicroRNA interactions in the vasculature / Clin. Pharmacol. Ther 99:494~501
Cao, M. X. / 2017 / The crosstalk between lncRNA and microRNA in cancer metastasis : orchestrating the epithelial-mesenchymal plasticity / Oncotarget 8:12472~12483
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