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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제4호
- 발행연도
- 2020.1
- 수록면
- 540 - 551 (12page)
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cats and humans in southeastern Brazil. The systemic disease prevails in cats and in humans, with the symptoms restricted to the skin of immunocompetent individuals. Under these conditions, the prolonged treatment of animals and cases of recurrence justify the discovery of new treatments for sporotrichosis. This work addresses the antifungal activity of silver salts of Keggin-type heteropolyacid salts (Ag-HPA salts) such as Ag3[PW12O40], Ag6[SiW10V2O40], Ag4[SiW12O40] and Ag3[PMo12O40] and interactions with the antifungal drugs itraconazole (ITC), terbinafine (TBF) and amphotericin B (AMB) on the yeast and mycelia forms of Sporothrix spp. Sporothrix spp. yeast cells were susceptible to Ag-HPA salts at minimum inhibitory concentration (MIC) values ranging from 8 to 128 μg/ml. Interactions between Ag3[PW12O40] and Ag3[PMo12O40] with itraconazole and amphotericin B resulted in higher antifungal activity with a reduction in growth and melanization. Treated cells showed changes in cell membrane integrity, vacuolization, cytoplasm disorder, and membrane detachment. Promising antifungal activity for treating sporotrichosis was observed for the Ag-HPA salts Ag3[PMo12O40] and Ag3[PW12O40], which have a low cost, high yield and activity at low concentrations. However, further evaluation of in vivo tests is still required.
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참고문헌 (49)
참고문헌 신청
Barros MB / 2011 / Sporothrix schenckii and Sporotrichosis / Clin. Microbiol. Rev. 24:633~654
López-Romero E / 2011 / Sporothrix schenckii complex and sporotrichosis, an emerging health problem / Future Microbiol 6:85~102
Borges TS / 2013 / Isolation of Sporothrix schenckii from the claws of domestic cats(indoor and outdoor)and in captivity in São Paulo(Brazil) / Mycopathol 176:129~137
Freitas DFS / 2014 / Infection in HIV-Infected Patients in Rio de Janeiro, Brazil / PLoS Negl. Trop. Dis 8:e3110
Kauffman CA / 2007 / Clinical practice guidelines for the management of sporotrichosis : 2007 update by the infectious diseases society of America / Clin. Infect. Dis 45:1255~1265
López-Romero E / 2011 / Sporothrix schenckii complex and sporotrichosis, an emerging health problem / Future Microbiol 6:85~102
Borges TS / 2013 / Isolation of Sporothrix schenckii from the claws of domestic cats(indoor and outdoor)and in captivity in São Paulo(Brazil) / Mycopathol 176:129~137
Freitas DFS / 2014 / Infection in HIV-Infected Patients in Rio de Janeiro, Brazil / PLoS Negl. Trop. Dis 8:e3110
Kauffman CA / 2007 / Clinical practice guidelines for the management of sporotrichosis : 2007 update by the infectious diseases society of America / Clin. Infect. Dis 45:1255~1265
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