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자료유형
학술저널
저자정보
김명옥 (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) 최완성 (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) 이봉희 (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) 조경재 (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) 서숙재 (Department of Biology, College of Natural Sciences, Gyeongsang National University) 강성구 (Department of Biology, College of Natural Sciences, Inje University) 김경진 (Department of Molecular Biology and Research Center for Cell Differentiation, College of Natural Sciences, Seoul National University) 백상호 (Department of Anatomy, College of Medicine, Seoul National University)
저널정보
한국통합생물학회 Korean journal of biological sciences Korean journal of biological sciences 제1권 제3호
발행연도
1997.1
수록면
497 - 505 (9page)

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Dopamine plays diverse roles in the fetal brain development and differentiation. However, the development of the dopaminergic neurons and its receptors has not been fully understood. In our studies, in situ hybridization and immunohistochemical methods were used to investigate the ontogeny of dopaminergic neurons and its receptor subtypes during the fetal development of the rat. In situ hybridization data showed that dopamine $D_1$ and $D_2$ receptor mRNAs were expressed in the ventricular and subventricular zones of ganglionic eminence, thalamus, hypothalamus, and cortical neuroepithelium on gestational day 13. Expression of dopamine $D_1$ and $D_2$ receptors during gestational days 17 and 19 reached the same or similar level of that in the adult brain. Expression of $D_1$ receptor mRNA preceded that of $D_2$ receptor mRNA in the early developmental stage, although this pattern was reversed with the sharp increase of $D_2$ receptor mRNA soon after. $D_2$ receptor mRNA was expressed in substantia nigra of mesencephalon of the fetal rat brain. However, $D_1$ receptor mRNA was not detected in substantia nigra. Our results indicate that dopamine might function in the fetal brain during the early gestational period.

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