지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 178 - 188 (11page)
이용수
초록· 키워드
오류제보하기
The stress responses in human body lead to secretion of cortisol hormone. The present study investigated the cellular responses on cell growth and cellular differentiation into adipocytes by exposure of synthetic stress hormone, dexamethasone (DEX) in various human cancer and normal cells. After prolonged exposure of cells with $1{\mu}g/ml$ DEX for 2 weeks, population doubling time (PDT) was significantly (P < .05) increased by inhibited cell growth in A-549 and MCF-7 cancer cells, and was unchanged in MDA-MB-231 cancer cells, normal MRC-5 fibroblasts, umbilical cord matrix-derived mesenchymal stem cells (UCMSCs) and dental papilla tissue-derived mesenchymal stem cells (DSCs). Whereas, PDT was significantly (P < .05) decreased in U87-MG cancer cells by increased cell growth. Glucose uptake was significantly (P < .05) increased in all the cancer cell lines compared to that in normal cell lines. Further, adiposome-like vesicles were noted in A-549 and MCF-7 cancer cells indicating retarded cell growth by DEX treatment, and the vesicles were stained with Oil-Red O solution. Further, the expression of adipocyte-specific genes such as glucose transporter type 4 (GLUT4), glucocorticoid receptors ${\beta}$ ($GR{\beta}$) and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) were significantly (P < .05) increased in A-549 and MCF-7 with lipid vesicles. The level of telomerase activity was found to be significantly (P < .05) downregulated in DEX-treated A-549 and MCF-7 cancer cells. Our results have clearly shown that DEX treatment induces inhibition of cell growth by differentiating into adipocyte-like cells in dexamethasone sensitive cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Ali AT / 2013 / Adipocyte and adipogenesis / Eur J Cell Biol 92:229~236
Allaman I / 2004 / Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes / J Neurochem 88:900~908
Arnoult N / 2015 / Complex interactions between the DNA-damage response and mammalian telomeres / Nat Struct Mol Biol 22:859~866
Arya SK / 1984 / Dexamethasonemediated inhibition of human T cell growth factor and gamma-interferon messenger RNA / J Immunol 133:273~276
Azzalin A1 / 2017 / Inhibitors of GLUT/SLC2A enhance the action of BCNU and temozolomide against high-grade gliomas / Neoplasia 19:364~373
Allaman I / 2004 / Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes / J Neurochem 88:900~908
Arnoult N / 2015 / Complex interactions between the DNA-damage response and mammalian telomeres / Nat Struct Mol Biol 22:859~866
Arya SK / 1984 / Dexamethasonemediated inhibition of human T cell growth factor and gamma-interferon messenger RNA / J Immunol 133:273~276
Azzalin A1 / 2017 / Inhibitors of GLUT/SLC2A enhance the action of BCNU and temozolomide against high-grade gliomas / Neoplasia 19:364~373
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Study of mitochondria depolarization by plasma activated medium on cancer cell lines
한국진공학회 학술발표회초록집
2021 .02
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
Fabrication of a 3D cell chip for evaluation of anticancer drug on cancer cell
한국진공학회 학술발표회초록집
2016 .08
-
Inhibitory Effects and Molecular Mechanism of Adipocyte Differentiation by Rosae laevigata Fructus Ethanol Extracs
한국미생물·생명공학회지
2016 .01
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
-
Cell Death Inhibition Effect of Antioxidant Activity by 630 and 850 nm LEDs in RAW264.7 Cells
Current Optics and Photonics
2024 .10
-
지방세포로의 분화를 통한 악성 종양의 치료 가능성
생명과학회지
2023 .06
-
익모초 추출물의 항산화 효과 및 MCF-7 유방암 세포주의 성장억제 유도에 관한 연구
한국지역사회생활과학회지
2018 .11
-
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines
Journal of Microbiology and Biotechnology
2018 .01
-
Homeostatic balance of histone acetylation and deconstruction of repressive chromatin marker H3K9me3 during adipocyte differentiation of 3T3-L1 cells
Genes & Genomics
2018 .01
-
Cross talk eliminated six-color detection of single cell imaging; application to monitoring obesity-induced insulin resistance in adipocyte and HepG2 cell co-culture
한국분석과학회 학술대회
2017 .11
-
곰보배추 추출물의 항산화 활성 및 MCF-7 유방암세포에서의 Apoptosis 유도 효과
한국지역사회생활과학회지
2018 .05
-
Brief guide to senescence assays using cultured mammalian cells
Molecules and Cells
2024 .01
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Single-Cell Molecular Barcoding to Decode Multimodal Information Defining Cell States
Molecules and Cells
2023 .02
-
Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes
Molecules and Cells
2020 .01
-
Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells
Nutrition Research and Practice
2015 .02
-
Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells
Nutrition Research and Practice
2015 .02
-
암줄기세포와 종양 미세환경에 대한 고찰
생명과학회지
2024 .06
-
Cytotoxicity and inhibition cell growth assessment in lung epithelial cell A549 of cinnamaldehyde
한국분석과학회 학술대회
2017 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0