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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 166 - 177 (12page)
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Plant essential oils are defined as fragrant volatile oils extracted from leaves, stems, fruits, flowers, and roots of a plant. Such oils are composed of multiple components and multiple functions. By accumulation of inductive information, various plant essential oils have been studied for using in therapeutic medicine for various diseases. Despite of the apparent advantages of essential oils as a source of therapeutic medicines, plant essential oils have many limitations, including cytotoxic side effects. Therefore, it is necessary to evaluate the toxicity and the mechanisms of cytotoxicity of such oils. In this study, we evaluated the cytotoxicity to human-derived cell lines of 10 plant essential oils provided by National Institute of Forest Science (i.e., Larix kaempferi; Abies holophylla; Zanthoxylum ailanthoides; Pinus parviflora; Tsuga sieboldti; Chamaecyparis pisifera; Cryptomeria japonica; Pinus densiflora; Illicium anisatum; Pinus thunbergii). Cytotoxicity evaluations were accomplished by using CCK-assays and PCR-based cytotoxicity-related marker gene analyses with A549 cell line, and the Detroit551 cell line which are lung and skin cell line. The genes were analyzed included caspase-3 has a role in cell apoptosis, and the other cyclinA, cyclinB, cyclinD, and cyclinE regulated cell cycling for the cell proliferation. By examining the five cytotoxicity-related marker genes by performing real-time PCR and examined the cytostatic gene regulation associated with the various essential oils. The results of this study showed that the degree of cytotoxicity and the cytostatic gene regulation which could give precious information for using the plant essential oil for the clinical usages.
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참고문헌 (27)
참고문헌 신청
Bravo, R. / 1980 / A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells / The Journal of Cell Biology 84(3):795~802
Citron, B.A. / 2000 / Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death / Experimental Neurology 166(2):213~226
Duronio, R.J. / 2013 / Signaling pathways that control cell proliferation / Cold Spring Harbor Perspectives in Biology 5(3):a008904
Elledge, S.J / 1996 / Cell cycle checkpoints: preventing an identity crisis / Science 274(5293):1664~1672
Galindo, L.A. / 2010 / Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil / Jounal of Nature Medicine 64(4):436~441
Citron, B.A. / 2000 / Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death / Experimental Neurology 166(2):213~226
Duronio, R.J. / 2013 / Signaling pathways that control cell proliferation / Cold Spring Harbor Perspectives in Biology 5(3):a008904
Elledge, S.J / 1996 / Cell cycle checkpoints: preventing an identity crisis / Science 274(5293):1664~1672
Galindo, L.A. / 2010 / Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil / Jounal of Nature Medicine 64(4):436~441
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