Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit Escherichia coli Persistence and Biofilm Formation

Jin Xing; Zhou Jiacheng; Richey Gabriella; Wang Mengya; Hong Sung Min Choi; 홍석훈

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자료유형: 학술저널

저자정보: Jin Xing (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616) Zhou Jiacheng (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616) Richey Gabriella (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616) Wang Mengya (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616) Hong Sung Min Choi (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616) 홍석훈 (Department of Chemical and Biological Engineering Illinois Institute of Technology Chicago IL 60616)

저널정보: 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제1호

발행연도: 2021.1

수록면: 130 - 136 (7page)

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Persister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating persister cells is challenging, owing to their tolerance to conventional antibiotics, which cannot kill cells in a metabolically dormant state. A high frequency of persisters in biofilms makes inactivating biofilm cells more difficult, because the biofilm matrix inhibits antibiotic penetration. Fatty acids may be promising candidates as antipersister or antibiofilm agents, because some fatty acids exhibit antimicrobial effects. We previously reported that fatty acid ethyl esters effectively inhibit Escherichia coli persister formation by regulating an antitoxin. In this study, we screened a fatty acid library consisting of 65 different fatty acid molecules for altered persister formation. We found that undecanoic acid, lauric acid, and N-tridecanoic acid inhibited E. coli BW25113 persister cell formation by 25-, 58-, and 44-fold, respectively. Similarly, these fatty acids repressed persisters of enterohemorrhagic E. coli EDL933. These fatty acids were all medium-chain saturated forms. Furthermore, the fatty acids repressed Enterohemorrhagic E. coli (EHEC) biofilm formation (for example, by 8-fold for lauric acid) without having antimicrobial activity. This study demonstrates that medium-chain saturated fatty acids can serve as antipersister and antibiofilm agents that may be applied to treat bacterial infections.

#E. coli #persister cells #biofilms #medium-chain saturated fatty acids

참고문헌 (52)

참고문헌 신청

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