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논문 기본 정보

자료유형
학술저널
저자정보
Botta Amy (Department of Biology York University Toronto ON Canada.) Barra Nicole G. (Department of Biochemistry and Biomedical Sciences Farncombe Family Digestive Health Research Insti) Lam Nhat Hung (Department of Biology York University Toronto ON Canada.) Chow Samantha (Department of Biology York University Toronto ON Canada.) Pantopoulos Kostas (Lady Davis Institute for Medical Research Jewish General Hospital and Department of Medicine McGill) Schertzer Jonathan D. (Department of Biochemistry and Biomedical Sciences Farncombe Family Digestive Health Research Insti) Sweeney Gary (Department of Biology York University Toronto ON Canada.)
저널정보
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제10권 제2호
발행연도
2021.1
수록면
160 - 183 (24page)

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Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Although iron is well characterized as a frequent traveling companion of metabolic disease, the role of iron is underappreciated because the mechanisms of iron's influence on host metabolism are poorly characterized. Both iron deficiency and excessive amounts leading to iron overload can have detrimental effects on cardiometabolic health. Optimal iron homeostasis is critical for regulation of host immunity and metabolism in addition to regulation of commensal and pathogenic enteric bacteria. In this article we review evidence to support the notion that altering composition of the gut microbiome may be an important route via which iron impacts cardiometabolic health. We discuss reshaping of the microbiome by iron, the physiological significance and the potential for therapeutic interventions.

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