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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 259 - 267 (9page)
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Background Recent studies have demonstrated that genes related to bitter taste receptors (TAS2Rs) on various chromosomes are expressed in extra-oral organs of various animals. The bitter taste receptor TAS2R14 is conserved among primate species and shows broad ligand sensitivity. Mice have a number of orthologues to primate TAS2R14 located in tandem on chromosome 16; however, their expression patterns are not unique. Objective We characterized the expression of TAS2R14 in various cell types in the intestines of the rhesus macaque and evaluated its role in hormone production in the gut. Methods TAS2R14 expression was examined in the intestines of rhesus macaques, a common non-human primate model, by RT-qPCR and immunohistochemical staining. Results Mean expression levels of TAS2R14 in the duodenum, ileum, and colon were similar to each other and were lower than those in circumvallate papillae. An immunohistochemical analysis revealed TAS2R14 immunoreactivity in enteroendocrine cells positive for cholecystokinin, serotonin, and the G protein GNAT3. Conclusion These results suggest that primate TAS2R14 is broadly expressed in the intestine, mainly in enteroendocrine cells, and promotes gut hormone secretion in response to bitter stimuli.
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참고문헌 (22)
참고문헌 신청
Constanza Alcaino / 2018 / A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release / Proceedings of the National Academy of Sciences 115(32):E7632
Maik Behrens / 2011 / Gustatory and extragustatory functions of mammalian taste receptors / Physiology & Behavior 105(1):4~13
Behrens M / 2012 / Immunohistochemical detection of TAS2R38 protein in human taste cells / PLoS ONE 7:e40304
Thomas Braun / 2007 / Enterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants / Gastroenterology 132(5):1890~1901
Josiane Fakhry / 2017 / Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine / Cell and Tissue Research 369(2):245~253
Maik Behrens / 2011 / Gustatory and extragustatory functions of mammalian taste receptors / Physiology & Behavior 105(1):4~13
Behrens M / 2012 / Immunohistochemical detection of TAS2R38 protein in human taste cells / PLoS ONE 7:e40304
Thomas Braun / 2007 / Enterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants / Gastroenterology 132(5):1890~1901
Josiane Fakhry / 2017 / Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine / Cell and Tissue Research 369(2):245~253
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