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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 137 - 143 (7page)
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Obesity is associated with inflammatory status and linked with metabolic syndrome. Interaction between adipocytes and macrophages aggravates inflammation and leads to insulin resistance in adipocytes. Resveratrol improved reportedly obesity-related inflammatory responses, but the effects of resveratrol on the production of inflammatory mediators and glucose metabolism in inflamed adipose tissue is not completely known. In this study, we investigated the effects of resveratrol on inflammatory change and insulin resistance in the coculture of hypertrophied 3T3-L1 adipocytes and RAW 264.7 macrophages. Resveratrol decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1b, tumor necrosis factor-a, inducible nitric oxide synthesis, and cyclooxygenase-2 in the coculture. Resveratrol increased glucose uptake by stimulating the phosphorylation of IRS-1 and AKT in the coculture. These results support that resveratrol have beneficial effect on inflammation and insulin resistance in inflamed adipose tissue.
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참고문헌 (33)
참고문헌 신청
Bastard JP / 2002 / Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro / J Clin Endocrinol Metab 87:2084~2089
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25:4~7
Fantuzzi G / 2005 / Adipose tissue, adipokines, and inflammation / J Allergy Clin Immunol 115:911~919
Ferna´ndez-Real JM / 2003 / Insulin resistance and chronic cardiovascular inflammatory syndrome / Endocr Rev 24:278~301
Gregor MF / 2011 / Inflammatory mechanisms in obesity / Annu Rev Immunol 29:415~445
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25:4~7
Fantuzzi G / 2005 / Adipose tissue, adipokines, and inflammation / J Allergy Clin Immunol 115:911~919
Ferna´ndez-Real JM / 2003 / Insulin resistance and chronic cardiovascular inflammatory syndrome / Endocr Rev 24:278~301
Gregor MF / 2011 / Inflammatory mechanisms in obesity / Annu Rev Immunol 29:415~445
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