지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 388 - 393 (6page)
- DOI
- 10.4283/JMAG.2022.27.4.388
이용수
초록· 키워드
오류제보하기
The suppression of cytokine storm in severe coronavirus disease 2019 (COVID-19) patients can be treated with monoclonal antibody therapy against CD3 for T cell receptor inhibition. An optimized liquid phase as a CD3 antibody-magnetic nanoparticle (Ab-MNP) conjugate can inhibit the overactivation of T cells. We aim to analyze the distribution of Fe in the spleen after acute administration of silica-conjugated amine magnetite (Fe₃O₄) nanoparticles (35 nm) delivered by intravenous injection. The Fe element distribution and concentration levels in spleen tissue were analyzed using energy dispersive spectroscopy (EDS) and inductively coupled plasmamass spectrometry (ICP-MS). The experimental result is a difference in the concentration of Fe elements, which was 1.89×10³ mg/kg in the spleen of a control mouse not administered with MNPs, whereas increases significantly to 1.93×10³ mg/kg in that of a mouse administered with MNPs. Further, time kinetic analysis of biochemical and immunological parameters is required to confirm its suitability in bio-administration.
목차
1. Introduction
2. Materials and Methods
3. Results and Discussion
4. Conclusion
References
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