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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 607 - 612 (6page)
- DOI
- 10.14348/molcells.2017.0151
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초록· 키워드
오류제보하기
When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the devel-opment of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.
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등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Amaravadi, R. K. / 2007 / Autophagy inhibition enhances therapy-induced apoptosis in a Mycinduced model of lymphoma / J. Clin. Invest 117:326~336
Boya, P. / 2013 / Emerging regulation and functions of autophagy / Nat. Cell Biol 15:713~720
Capparelli, C. / 2012 / CDK inhibitors (p16/p19/p21). induce senescence and autophagy in cancer-associated fibroblasts, "fueling"tumor growth via paracrine interactions, without an increase in neoangiogenesis / Cell Cycle 11:3599~3610
Childs, B. G. / 2015 / Cellular senescence in aging and age-related disease: from mechanisms to therapy / Nat. Med 21:1424~1435
Choi, A. M. / 2013 / Autophagy in human health and disease / N. Engl. J. Med 368:1845~1846
Boya, P. / 2013 / Emerging regulation and functions of autophagy / Nat. Cell Biol 15:713~720
Capparelli, C. / 2012 / CDK inhibitors (p16/p19/p21). induce senescence and autophagy in cancer-associated fibroblasts, "fueling"tumor growth via paracrine interactions, without an increase in neoangiogenesis / Cell Cycle 11:3599~3610
Childs, B. G. / 2015 / Cellular senescence in aging and age-related disease: from mechanisms to therapy / Nat. Med 21:1424~1435
Choi, A. M. / 2013 / Autophagy in human health and disease / N. Engl. J. Med 368:1845~1846
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