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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 조윤희
- 발행연도
- 2016
- 저작권
- 경희대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Skin pH, an indicator to skin health, is maintained by various organic factors, which include lactate, free amino acid (FAA) and free fatty acid (FFA). As skin became aged or ill, skin pH becomes less acidic and functional food has been developed to maintain acidic skin pH of skin. In this study, we determined the dietary efficacy of 1% green tea extract (GTE), of which epigallocatechin-3-gallate (EGCG) is a major ingredient, on skin pH of photoaged mice, as measured by epidermal levels of lactate, FAA and FFA. The protein expression and activity of lactate dehydrogenase (LDH), an enzyme of pyruvate reduction for lactate generation, was also determined. Albino hairless mice were fed a control diet (group UV+) or a diet with 1% GTE (group GTE) in parallel with UVB irradiation for 10 week. A normal control group was fed a control diet without UVB irradiation for 10 weeks (group UV-). In group UV+, skin pH was higher (less acidic) than in group UV-. Inversely, epidermal levels of lactate and FFA as well as protein expression and activity of LDH were less than in group UV-; these levels, but not epidermal levels of FFA, in group GTE were similar to levels in group UV+. Although epidermal levels of FAA was similar in group UV- and UV+, it was increased in group GTE more than in group UV+. We demonstrated that dietary 1% GTE normalized skin pH with increased levels of lactate and FAA, as well as with increased protein expression and activity of LDH in the epidermis of UVB irradiated hairless mouse.
목차
TABLE OF CONTENTChapter I . Literature review1. Skin aging and skin pH1.1 Skin aging1.2 Skin pH2. Skin pH related factors2.1 Latate and lactate dehydrogenase2.2 Free amino acid2.3 Free fatty acid3. Green tea extract and skin photoging3.1 Bioactivity of green tea3.2 The dietary effect of GTE on skin photoagingReferences for literature reviewChapter II . 자외선 조사와 병행된 녹차 식이 공급이 무모생쥐의 표피 pH 관련 인자 함량 및 lactate dehydrogenase 효소의 단백질 발현에 미치는 영향AbstractIntroductionMaterials and methodsResultsDiscussionSummaryReferences
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