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논문 기본 정보

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학술저널
저자정보
김경윤 (동신대학교) 심기철 (동신대학교) 김계엽 (동신대학교) 최찬헌 (동신대학교) 정재곤 (옥반식품) 정재선 (옥반식품) 정현우 (동신대학교)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제25권 제6호
발행연도
2011.12
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1,000 - 1,007 (8page)

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This study was conducted to determine the analgesic effect of onion and acanthopanax senticosus mixture extract using the rheumatoid arthritis rat model. Rheumatoid arthritis model was made by the intradermal injection of type Ⅱ collagen emulsified. Rats were divided into four groups: (1) Sham group(n=5), (2) Control group(administered DW 3 ㎖/1 day after RA induced, n=7), (3) Experimental group Ⅰ(administered Onion extractor 600 ㎎/3 ㎖/1 day after RA induced, n=7). (4) Experimental group Ⅲ(administered Onion and Acanthopanax senticosus mixture extractor 600 ㎎/3 ㎖/1 day after RA induced, n=7). After that, we examined the arthritic index, paw edema, pain threshold at 1st, 14th, 28th days. And also we examined histopathologic study(safranin-O green), immunohistochamical stain(COX-2) of knee joint at 28th days. Arthritic index, paw edema and pain threshold test were decrease in experimental group Ⅰ,Ⅱ than control group. Especially group Ⅱ was most significantly inhibit effect than the other groups at 28th days. On the histopathologic view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. All experimental groups were COX-2 positive cells in the immunohistological stain of the knee joint were significantly decreased compared with control group. Especially group Ⅱ was most significantly decreased than the other groups at 28th days. Onion and Acanthopanax senticosus mixture extractor can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of Onion and Acanthopanax senticosus.

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