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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제5호
- 발행연도
- 2018.1
- 수록면
- 707 - 717 (11page)
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초록· 키워드
오류제보하기
Leukocytes are reportedly the first line of the innate immune defense and essential for the control of common bacterial infections. Therefore, in this work, the antibacterial activity of crocodile leukocyte extract against Propionibacterium acnes was evaluated, and we also characterized the related activity of skin infection. The leukocyte extract showed the minimum inhibitory concentration to be 100 μg/ml to P. acnes. SEM imaging demonstrated that the leukocyte extract adversely affected P. acnes cell permeability in a concentration-dependent manner. Furthermore, the crocodile leukocyte extract could significantly reduce proinflammatory markers and decrease inflammatory signs in infected mouse ears. The crude leukocyte extract was further purified using FPLC and RP-HPLC. The resulting fraction F5 was indicated as the anti-acne peptide-containing fraction. The molecular mass of the peptide contained in F5 was calculated to be 4,790.5 Da. N-Terminal sequencing revealed the amino acid sequence as GPEPVPAIYQ, which displays similarities to immunoglobulin A and leucine-rich repeat neuronal protein. This is the first reported amino acid sequence of a crocodile leukocyte extract that possesses anti-acne activity. To attempt to use it in a prototype cosmetic, an anti-acne gel containing crude crocodile leukocyte extract was formulated, resulting in seven gel formulations (G1, G2, G3, G4, G5, G6, and G7). The formulations G5, G6, and G7 exhibited 2-fold higher anti-acne activity than G1-G4. Investigation of accelerating stability studies of anti-acne gel formulations G5, G6, and G7 demonstrated that a low storage temperature (4ºC) is suitable for maintaining the physical properties and biological activity of the anti-acne gel products.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Williams CH / 2012 / Acne vulgaris / Lancet 379:361~372
Ryu S / 2015 / Suppression of Propionibacterium acnes infection and the associated inflammatory response by the antimicrobial peptide P5 in mice / PLoS One 10:e0132619
Sinha P / 2014 / New perspectives on anti-acne plant drugs: contribution to modern therapeutics / Biomed. Res. Int. 2014:301304
de Boer HJ / 2014 / Medicinal plants for women's healthcare in Southeast Asia: a meta-analysis of their traditional use, chemical constituents, and pharmacology / J. Ethnopharmacol. 151:747~767
Phosri S / 2014 / An investigation of antioxidant and anti-inflammatory activities from blood components of crocodile (Crocodylus siamensis) / Protein J. 33:484~492
Ryu S / 2015 / Suppression of Propionibacterium acnes infection and the associated inflammatory response by the antimicrobial peptide P5 in mice / PLoS One 10:e0132619
Sinha P / 2014 / New perspectives on anti-acne plant drugs: contribution to modern therapeutics / Biomed. Res. Int. 2014:301304
de Boer HJ / 2014 / Medicinal plants for women's healthcare in Southeast Asia: a meta-analysis of their traditional use, chemical constituents, and pharmacology / J. Ethnopharmacol. 151:747~767
Phosri S / 2014 / An investigation of antioxidant and anti-inflammatory activities from blood components of crocodile (Crocodylus siamensis) / Protein J. 33:484~492
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