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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 839 - 848 (10page)
이용수
초록· 키워드
오류제보하기
Coptis chinensis (CC) is widely used in Asian countries to treat inflammatory diseases. We investigated the anti-inflammatory activity of the aqueous fraction separated from CC extract and of berberine, its key bioactive component, in human keratinocytes and the possible molecular mechanisms underlying this. Treating HaCaT keratinocytic cells with heat-killed Propionibacterium acnes induced nitric oxide and proinflammatory cytokine (e.g., tumor necrosis factor-α, interleukin (IL)-1β, and IL-8) production and their mRNA expression; these effects were suppressed by pretreatment with the aqueous fraction or berberine, which also suppressed the phosphorylation of ERK, JNK, and p38 kinases and the nuclear expression of nuclear factor (NF)-κB p65 in P. acnes-stimulated cells. Thus, the aqueous fraction and berberine effectively exerted anti-inflammatory activities by suppressing mitogen-activated protein kinase and NF-κB signaling pathways in human keratinocytes and may be used for treating P. acnes-induced inflammatory skin diseases.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Omer H / 2017 / Understanding the role of Propionibacterium acnes in acne vulgaris: the critical importance of skin sampling methodologies / Clin. Dermatol. 35:118~129
Dessinioti C / 2010 / The role of Propionibacterium acnes in acne pathogenesis: facts and controversies / Clin. Dermatol. 28:2~7
Farrar MD / 2004 / Acne: inflammation / Clin. Dermatol. 22:380~384
Kim J / 2002 / Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses / J. Immunol. 169:1535~1541
Kollisch G / 2005 / Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes / Immunology 114:531~541
Dessinioti C / 2010 / The role of Propionibacterium acnes in acne pathogenesis: facts and controversies / Clin. Dermatol. 28:2~7
Farrar MD / 2004 / Acne: inflammation / Clin. Dermatol. 22:380~384
Kim J / 2002 / Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses / J. Immunol. 169:1535~1541
Kollisch G / 2005 / Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes / Immunology 114:531~541
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