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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제5호
- 발행연도
- 2015.1
- 수록면
- 598 - 605 (8page)
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The cohesin complex holds sister chromatids together and prevents premature chromosome segregation until the onset of anaphase. Mcd1 (also known as Scc1), the α-kleisin subunit of cohesin, is a key regulatory subunit of the mitotic cohesin complex and is required for maintaining sister chromatid cohesion, chromosome organization, and DNA repair. We investigated the function of Mcd1 in meiosis by ectopically expressing Mcd1 during early meiotic prophase I in Saccharomyces cerevisiae. Mcd1 partially regulated the progression of meiotic recombination, sister chromatid separation, and nuclear division. DNA physical analysis during meiotic recombination showed that Mcd1 induced double-strand breaks (DSBs) but negatively regulated homologous recombination during DSB repair; Mcd1 expression delayed post-DSB stages, leading to inefficiencies in the DSB-to-joint molecule (JM) transition and subsequent crossover formation. These findings indicate that meiotic cells undergo Mcd1-mediated DSB formation during prophase I, and that residual Mcd1 could regulate the progression of JM formation during meiotic recombination.
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참고문헌 (26)
참고문헌 신청
Brar GA / 2006 / Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis / Nature 441 : 532 ~ 536
Brar GA / 2009 / The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing / Mol. Biol. Cell 20 : 1030 ~ 1047
Guacci V / 1993 / Structure and function of chromosomes in mitosis of budding yeast. Cold Spring Harb / Symp. Quant. Biol 58 : 677 ~ 685
Guacci V / 1997 / A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae / Cell 91 : 47 ~ 57
Heidinger-Pauli JM / 2008 / The kleisin subunit of cohesin dictates damage-induced cohesion / Mol. Cell 31 : 47 ~ 56
Brar GA / 2009 / The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing / Mol. Biol. Cell 20 : 1030 ~ 1047
Guacci V / 1993 / Structure and function of chromosomes in mitosis of budding yeast. Cold Spring Harb / Symp. Quant. Biol 58 : 677 ~ 685
Guacci V / 1997 / A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae / Cell 91 : 47 ~ 57
Heidinger-Pauli JM / 2008 / The kleisin subunit of cohesin dictates damage-induced cohesion / Mol. Cell 31 : 47 ~ 56
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