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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제6호
- 발행연도
- 2017.6
- 수록면
- 1,198 - 1,203 (6page)
- DOI
- 10.4014/jmb.1701.01016
이용수
초록· 키워드
오류제보하기
Hrr25, a casein kinase 1 δ/ε homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Kleckner N / 2004 / A mechanical basis for chromosome function / Proc. Natl. Acad. Sci. USA 101:12592~12597
Zickler D / 1999 / Meiotic chromosomes: integrating structure and function / Annu. Rev. Genet 33:603~754
Hochwagen A / 2006 / Checking your breaks surveillance mechanisms of meiotic recombination / Curr. Biol 16:217~228
Uhlmann F / 2000 / Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast / Cell 103:375~386
Ciosk R / 1998 / An Esp1/Pds1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast / Cell 93:1067~1076
Zickler D / 1999 / Meiotic chromosomes: integrating structure and function / Annu. Rev. Genet 33:603~754
Hochwagen A / 2006 / Checking your breaks surveillance mechanisms of meiotic recombination / Curr. Biol 16:217~228
Uhlmann F / 2000 / Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast / Cell 103:375~386
Ciosk R / 1998 / An Esp1/Pds1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast / Cell 93:1067~1076
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