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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제3호
- 발행연도
- 2018.1
- 수록면
- 349 - 356 (8page)
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Asterias amurensis is a marine organism that causes damage to the fishing industry worldwide; however, it has been considered a promising source of functional components. The present study aimed to investigate the immune-enhancing effects of fatty acids from three organs of A. amurensis on murine macrophages (RAW 264.7 cells). A. amurensis fatty acids boosted production of immune-associated factors such as nitric oxide (NO) and prostaglandin E2 in RAW 264.7 cells. A. amurensis fatty acids also enhanced the expression of critical immuneassociated genes, including iNOS, TNF-α, IL-1β, and IL-6, as well as COX-2. Western blotting showed that A. amurensis fatty acids stimulated the NF-κB and MAPK pathways by phosphorylation of NF-κB p-65, p38, ERK1/2, and JNK. A. amurensis fatty acids from different tissues resulted in different levels of NF-κB and MAPK phosphorylation in RAW 264.7 cells. The results increase our understanding of how A. amurensis fatty acids boost immunity in a physiological system, as a potential functional material.
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참고문헌 (41)
참고문헌 신청
Walls J / 2016 / Nutrient sensing, signal transduction and immune responses / Semin. Immunol. 28:396~407
Miccadei S / 2016 / Omega3 polyunsaturated fatty acids as immunomodulators in colorectal cancer: new potential role in adjuvant therapies / Front. Immunol. 7:486
Roche HM / 1999 / Unsaturated fatty acids / Proc. Nutr. Soc. 58:397~401
Ford JH / 2010 / Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging / Age (Dordr.) 32:231~237
Volpe JJ / 1976 / Mechanisms and regulation of biosynthesis of saturated fatty acids / Physiol. Rev. 56:339~417
Miccadei S / 2016 / Omega3 polyunsaturated fatty acids as immunomodulators in colorectal cancer: new potential role in adjuvant therapies / Front. Immunol. 7:486
Roche HM / 1999 / Unsaturated fatty acids / Proc. Nutr. Soc. 58:397~401
Ford JH / 2010 / Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging / Age (Dordr.) 32:231~237
Volpe JJ / 1976 / Mechanisms and regulation of biosynthesis of saturated fatty acids / Physiol. Rev. 56:339~417
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