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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 874 - 882 (9page)
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초록· 키워드
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Curcumin is known to possess various biological functions, including anti-inflammatory, antioxidative, and anti-cancer activities. Natural killer (NK) cells are large lymphocytes that directly kill cancer cells. However, many aggressive cancers, including breast cancer, were reported to escape the successful killing of NK cells in a tumor microenvironment. In this study, we investigated the anti-cancer effect of curcumin in coculture of human breast carcinoma MDA-MB-231 and NK (NK-92) cells. We found that curcumin had an immunestimulatory effect on NK-92 by increasing the surface expression of the CD16+ and CD56dim population of NK-92. We confirmed that the cytotoxic effect of NK-92 on MDA-MB-231 was significantly enhanced in the presence of curcumin, which was highly associated with the activation of Stat4 and Stat5 proteins in NK-92. Finally, this improved anticancer effect of curcumin was correlated with decreased expression of pErk and PI3K in MDA-MB-231.
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참고문헌 (35)
참고문헌 신청
Sinha D / 2012 / Chemopreventive and chemotherapeutic potential of curcumin in breast cancer / Curr. Drug Targets 13:1799~1819
Bengmark S / 2009 / Plant-derived health: the effects of turmeric and curcuminoids / Nutr. Hosp. 24:273~281
Jurenka JS / 2009 / Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research / Altern. Med. Rev. 14:141~153
Hussain Z / 2017 / Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: a sreview of new trends and future perspectives / Mater. Sci. Eng. C Mater. Biol. Appl. 77:1316~1326
Jin H / 2015 / Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway / Oncol. Rep. 34:2782~2789
Bengmark S / 2009 / Plant-derived health: the effects of turmeric and curcuminoids / Nutr. Hosp. 24:273~281
Jurenka JS / 2009 / Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research / Altern. Med. Rev. 14:141~153
Hussain Z / 2017 / Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: a sreview of new trends and future perspectives / Mater. Sci. Eng. C Mater. Biol. Appl. 77:1316~1326
Jin H / 2015 / Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway / Oncol. Rep. 34:2782~2789
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