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자료유형
학술저널
저자정보
Jung Ye-Jin (Department of R) Kim Hyun-Seok (Department of R) Jaygal Gunn (Department of R&D Research Center KookminBio Corporation Seoul 02826 Republic of Korea) Cho Hye-Rin (Technical Assistance Department (R&D Department) The Food Industrial Promotional Agency of Kore) Lee Kyung bae (Technical Assistance Department (R&D Department) The Food Industrial Promotional Agency of Kore) Song In-bong (Technical Assistance Department (R&D Department) The Food Industrial Promotional Agency of Kore) Kim Jong-Hoon (Department of Bio and Fermentation Convergence Technology Kookmin University Seoul 02707 Republic o) Kwak Mi-Sun (Department of Bio and Fermentation Convergence Technology Kookmin University Seoul 02707 Republic o) Han Kyung-Ho (Department of R&D Research Center KookminBio Corporation Seoul 02826 Republic of Korea) Bae Min-Jung (Technical Assistance Department (R&D Department) The Food Industrial Promotional Agency of Kore) 성문희 (국민대학교)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제5호
발행연도
2022.5
수록면
612 - 620 (9page)
DOI
10.4014/jmb.2111.11027

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Recent studies have revealed that probiotics and their metabolites are present under various conditions; however, the role of probiotic metabolites (i.e., postbiotics in pathological states) is controversial. Natural killer (NK) cells play a key role in innate and adaptive immunity. In this study, we examined NK cell activation influenced by a postbiotics mixture in response to gut microbiome modulation in stress-induced mice. In vivo activation of NK cells increased in the postbiotics mixture treatment group in accordance with Th1/Th2 expression level. Meanwhile, the Red Ginseng treatment group, a reference group, showed very little expression of NK cell activation. Moreover, the postbiotics mixture treatment group in particular changed the gut microbiome composition. Although the exact role of the postbiotics mixture in regulating the immune system of stressinduced mice remains unclear, the postbiotics mixture-induced NK cell activation might have affected gut microbiome modulation.

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