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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 1,007 - 1,021 (15page)
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초록· 키워드
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Cancer represents one of the most significant threats to human health on a global scale. Hence, the development of effective cancer prevention strategies, as well as the discovery of novel therapeutic agents against cancer, is urgently required. In light of this challenge, this research aimed to evaluate the effects of several potent bioactive peptides and proteins contained in crocodile white blood cell extract (cWBC) against LU-1, LNCaP, PC-3, MCF-7, and CaCo-2 cancer cell lines. The results demonstrate that 25, 50, 100, and 200 μg/ml cWBC exhibits a strong cytotoxic effect against all investigated cell lines (IC50 70.34−101.0 μg/ml), while showing no signs of cytotoxicity towards noncancerous Vero and HaCaT cells. Specifically, cWBC treatment caused a significant reduction in the cancerous cells’ colony forming ability. A remarkable suppression of cancerous cell migration was observed after treatment with cWBC, indicating potent antimetastatic properties. The mechanism involved in the cancer cell cytotoxicity of cWBC may be related to apoptosis induction, as evidenced by typical apoptotic morphology features. Moreover, certain cWBC concentrations induced significant overproduction of ROS and significantly inhibited the S-G2/M transition in the cancer cell. The molecular mechanisms of cWBC in apoptosis induction were to decrease Bcl-2 and XIAP expression levels and increase the expression levels of caspase-3, caspase-8, and p53. These led to a decrease in the expression level of the cell cycle-associated gene cyclin-B1 and the arrest of cell population growth. Consequently, these findings demonstrate the prospect of the use of cWBC for cancer therapy.
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참고문헌 (56)
참고문헌 신청
Shrestha LB / 2000 / Population aging in developing countries / Health Aff. (Millwood) 19:204~212
Yach D / 2004 / The global burden of chronic diseases: overcoming impediments to prevention and control / JAMA 291:2616~2622
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int. J. Cancer 136:359~386
Chen R / 2014 / Prostate cancer in Asia: a collaborative report / Asian J. Urol. 1:15~29
Hsu SC / 2007 / Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells / Anticancer Res 27:2377~2384
Yach D / 2004 / The global burden of chronic diseases: overcoming impediments to prevention and control / JAMA 291:2616~2622
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int. J. Cancer 136:359~386
Chen R / 2014 / Prostate cancer in Asia: a collaborative report / Asian J. Urol. 1:15~29
Hsu SC / 2007 / Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells / Anticancer Res 27:2377~2384
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