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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 165 - 174 (10page)
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초록· 키워드
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Glioblastoma multiforme is the most lethal malignant brain tumor. Despite many intensive studies, the prognosis of glioblastoma multiforme is currently very poor, with a median overall survival duration of 14 months and 2-year survival rates of less than 10%. Although viral infections have been emphasized as potential cofactors, their influences on pathways that support glioblastoma progression are not known. Some previous studies indicated that human Kaposi’s sarcoma-associated herpesvirus (KSHV) was detected in healthy brains, and its microRNA was also detected in glioblastoma patients’ plasma. However, a direct link between KSHV infection and glioblastoma is currently not known. In this study, we infected glioblastoma cells and glioma stem-like cells (GSCs) with KSHV to establish an in vitro cell model for KSHV-infected glioblastoma cells and glioma stem-like cells in order to identify virologic outcomes that overlap with markers of aggressive disease. Latently KSHV-infected glioblastoma cells and GSCs were successfully established. Additionally, using these cell models, we found that KSHV infection modulates the proliferation of glioma stem-like cells.
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참고문헌 (30)
참고문헌 신청
Wen PY / 2008 / Malignant gliomas in adults / N Engl. J. Med. 359:492~507
Nieder C / 2005 / Treatment of unresectable glioblastoma multiforme / Anticancer Res 25:4605~4610
Huse JT / 2010 / Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma / Nat. Rev. Cancer 10:319~331
Filatova A / 2013 / The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment / Biochim. Biophys. Acta 1830:2496~2508
Neman J / 2010 / Decreasing glioma recurrence through adjuvant cancer stem cell inhibition / Biologics 4:157~162
Nieder C / 2005 / Treatment of unresectable glioblastoma multiforme / Anticancer Res 25:4605~4610
Huse JT / 2010 / Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma / Nat. Rev. Cancer 10:319~331
Filatova A / 2013 / The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment / Biochim. Biophys. Acta 1830:2496~2508
Neman J / 2010 / Decreasing glioma recurrence through adjuvant cancer stem cell inhibition / Biologics 4:157~162
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