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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 515 - 522 (8page)
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초록· 키워드
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CD133, a pentaspan transmembrane glycoprotein, is generally used as a cancer stem cell marker in various human malignancies, but its biological function in cancer cells, especially in glioma cells, is largely unknown. Here, we demonstrated that forced expression of CD133 increases the expression of IL-1β and its downstream chemokines, namely, CCL3, CXCL3 and CXCL5, in U87MG glioma cells. Although there were no apparent changes in cell growth and sphere formation in vitro and tumor growth in vivo, in vitro trans-well studies and in vivo tumor xenograft assays showed that neutrophil recruitment was markedly increased by the ectopic expression of CD133. In addition, the clinical relevance between CD133 expression and IL-1β gene signature was established in patients with malignant gliomas. Thus, these results imply that glioma cells expressing CD133 are capable of modulating tumor microenvironment through the IL-1β signaling pathway.
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참고문헌 (31)
참고문헌 신청
Brat, D. J. / 2004 / Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population / Cancer Res 64:920~927
Brescia, P. / 2012 / Current strategies for identification of glioma stem cells: adequate or unsatisfactory? / J. Oncol 2012:376894
Brescia, P. / 2013 / CD133 is essential for glioblastoma stem cell maintenance / Stem Cells 31:857~869
Chen, K. / 2013 / Understanding and targeting cancer stem cells: therapeutic implications and challenges / Acta. Pharmacol. Sin 34:732~740
Eash, K. J. / 2010 / CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow / J. Clin. Invest 120:2423~2431
Brescia, P. / 2012 / Current strategies for identification of glioma stem cells: adequate or unsatisfactory? / J. Oncol 2012:376894
Brescia, P. / 2013 / CD133 is essential for glioblastoma stem cell maintenance / Stem Cells 31:857~869
Chen, K. / 2013 / Understanding and targeting cancer stem cells: therapeutic implications and challenges / Acta. Pharmacol. Sin 34:732~740
Eash, K. J. / 2010 / CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow / J. Clin. Invest 120:2423~2431
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