지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 71 - 77 (7page)
이용수
초록· 키워드
오류제보하기
Menadione is known as an anti-tumor factor. Many studies have reported the potential anti-cancer role of menadione against a range of cancer cell lines. In this study, the anti-cancer effects of menadione and the underlying molecular signaling involved in apoptosis was investigated in gastric cancer cell lines. The menadione treatment decreased the cell viability of MKN45 gastric cancer cells. The decreased cell viability was attributed to the induction of apoptosis, which was confirmed by the results indicating the activation of caspase-3 and -7 and the cleavage of PARP in Western blotting. The upstream regulatory molecules involved in apoptosis were investigated further and it was discovered that menadione reduced the expression of survivin, an inhibitor of upstream apoptosis proteins. In addition, a transcription factor –catenin, which is known to regulate survivin expression, was down-regulated by menadione. A previous report showed that menadione inhibited XIAP expression to induce apoptosis and induced G2/M cell cycle arrest in AGS cells. This study elucidated another inhibitory mechanism of menadione against gastric cancer cells in a different cell line. Although further studies will be needed, the inhibitory mechanism demonstrated in this study will help better understand the anti-cancer effects of menadione.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Al-Suhaimi E / 2014 / Molecular mechanisms of leptin and pro-apoptotic signals induced by menadione in HepG2 cells / Saudi J Biol Sci 21:582~588
Hassan GS / 2013 / Menadione / Profiles Drug Subst Excip Relat Methodol 38:227~313
Kim YJ / 2014 / Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion / Naunyn Schmiedebergs Arch Pharmacol 387:799~809
Osada S / 2008 / The utility of vitamin K3(menadione)against pancreatic cancer / Anticancer Res 28:45~50
Oztopcu-Vatan P / 2015 / Cytotoxic and apoptotic effects of menadione on rat hepatocellular carcinoma cells / Cytotechnology 67:1003~1009
Hassan GS / 2013 / Menadione / Profiles Drug Subst Excip Relat Methodol 38:227~313
Kim YJ / 2014 / Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion / Naunyn Schmiedebergs Arch Pharmacol 387:799~809
Osada S / 2008 / The utility of vitamin K3(menadione)against pancreatic cancer / Anticancer Res 28:45~50
Oztopcu-Vatan P / 2015 / Cytotoxic and apoptotic effects of menadione on rat hepatocellular carcinoma cells / Cytotechnology 67:1003~1009
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Menadione Sodium Bisulfite-Protected Tomato Leaves against Grey Mould via Antifungal Activity and Enhanced Plant Immunity
The Plant Pathology Journal
2021 .04
-
Differential Control Efficacies of Vitamin Treatments against Bacterial Wilt and Grey Mould Diseases in Tomato Plants
The Plant Pathology Journal
2016 .10
-
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway
Journal of Microbiology and Biotechnology
2021 .12
-
MiR-339 attenuates LPS-induced intestinal epithelial cells inflammatory responses and apoptosis by targeting TLR4
Genes & Genomics
2020 .01
-
Induction of p53-dependent Apoptosis by Resveratrol in Human Cancer Cells, A549 and SKOV3
한국미생물·생명공학회지
2016 .01
-
Study of mitochondria depolarization by plasma activated medium on cancer cell lines
한국진공학회 학술발표회초록집
2021 .02
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines
Journal of Microbiology and Biotechnology
2018 .01
-
AGS 인체 위암세포에서 황흑산에 의한 ROS 생성 및 caspase 활성 의존적 apoptosis 유발
생명과학회지
2015 .11
-
Siamese Crocodile White Blood Cell Extract Inhibits Cell Proliferation and Promotes Autophagy in Multiple Cancer Cell Lines
Journal of Microbiology and Biotechnology
2018 .01
-
Orostachys japonicus induce caspase-dependent apoptosis in HeLa human cervical cancer cells
Nutrition Research and Practice
2025 .02
-
Orostachys japonicus induce caspase-dependent apoptosis in HeLa human cervical cancer cells
Nutrition Research and Practice
2025 .02
-
Anti-Cancer Effect of Cordyceps militaris in Human Colorectal Carcinoma RKO Cells Via Cell Cycle Arrest and Mitochondrial Apoptosis
한국미생물학회 학술대회논문집
2015 .04
-
대장암세포주 HT29에서의 Treculia africana 추출물의 항산화 및 항암 활성 분석
생명과학회지
2015 .05
-
Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells
Journal of Microbiology and Biotechnology
2016 .01
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
The Effect of miR-361-3p Targeting TRAF6 on Apoptosis of Multiple Myeloma Cells
Journal of Microbiology and Biotechnology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0