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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 223 - 230 (8page)
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초록· 키워드
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Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or biochemical stimuli, remarkable platelet shape changes precede aggregation or adhesion. Platelets shape changes facilitate the formation and adhesion of platelet aggregates, but are readily reversible in contrast to the irrevocable characteristics of aggregation and adhesion. In this dynamic phenomenon, complex molecular signaling pathways and a host of diverse cytoskeleton proteins are involved. Platelet shape change is easily primed by diverse pro-thrombotic xenobiotics and stimuli, and its inhibition can modulate thrombosis, which can ultimately contribute to the development or prevention of thrombotic diseases. In this review, we discussed the current knowledge on the mechanisms of platelet shape change and also pathological implications and therapeutic opportunities for regulating the related cytoskeleton dynamics.
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등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Abrescia, P. / 2005 / Free radicals and antioxidants in cardiovascular diseases / Expert Rev. Cardiovasc. Ther 3:159~171
Bennett, J. S. / 1999 / The platelet cytoskeleton regulates the affinity of the integrin αIIbβ3 for fibrinogen / J. Biol. Chem 274:25301~25307
Berridge, M. J. / 2000 / The versatility and universality of calcium signalling / Nat. Rev. Mol. Cell Biol 1:11~21
Born, G. V. / 1978 / Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors / J. Physiol 280:193~212
Coller, B. S. / 2013 / Platelets / Academic Press :xix~xliv
Bennett, J. S. / 1999 / The platelet cytoskeleton regulates the affinity of the integrin αIIbβ3 for fibrinogen / J. Biol. Chem 274:25301~25307
Berridge, M. J. / 2000 / The versatility and universality of calcium signalling / Nat. Rev. Mol. Cell Biol 1:11~21
Born, G. V. / 1978 / Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors / J. Physiol 280:193~212
Coller, B. S. / 2013 / Platelets / Academic Press :xix~xliv
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