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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 170 - 176 (7page)
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초록· 키워드
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Thapsigargin (TG), a sarco/endoplasmic reticulum (ER) Ca<SUP>2+</SUP>-ATPase (SERCA) inhibitor, has been widely used as an agonist for platelet aggregation for decades. In this study, we investigated the effect of TG on the release of lactate dehydrogenase (LDH) for platelets and elucidated its mechanism. Platelet LDH release and platelet aggregation were increased by TG treatment; 1,000 nM of TG induced the complete lysis of platelets. Other agonists such as collagen (2.5 μg/mL), thrombin (0.1 U/mL), and ADP (10 mM) did not induce significant platelet LDH release despite platelet aggregation. Finally, we investigated the effects of pharmacological inhibitors on TG-induced platelet aggregation and LDH release. SP600125, a JNK inhibitor, and LY294002, a PI-3K inhibitor, inhibited TG-induced platelet LDH release but not platelet aggregation. Forskolin, an adenylyl cyclase activator, also inhibited LDH release without affecting platelet aggregation by TG. These results suggest that the TG-induced platelet aggregation was accompanied by LDH release but regulated by a different signaling pathway.
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참고문헌 (17)
참고문헌 신청
Adam F / 2008 / Mitogen-activated protein kinases in hemostasis and thrombosis / Journal of Thrombosis and Haemostasis 6:2007~2016
Al-Samkari H / 2019 / Lactate dehydrogenase is elevated in immune thrombocytopenia and inversely correlates with platelet count / British Journal of Haematology 187:e61~e64
Brüne B / 1991 / Calcium mobilization in human platelets by receptor agonists and calcium-ATPase inhibitors / FEBS Letters 284:1~4
Christenson JT / 1995 / The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release / Vasa 24:56~61
Collazos JM / 1987 / cAMP reduces the affinity of Ca2+-triggered secretion in platelets / FEBS Letters 215:183~186
Al-Samkari H / 2019 / Lactate dehydrogenase is elevated in immune thrombocytopenia and inversely correlates with platelet count / British Journal of Haematology 187:e61~e64
Brüne B / 1991 / Calcium mobilization in human platelets by receptor agonists and calcium-ATPase inhibitors / FEBS Letters 284:1~4
Christenson JT / 1995 / The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release / Vasa 24:56~61
Collazos JM / 1987 / cAMP reduces the affinity of Ca2+-triggered secretion in platelets / FEBS Letters 215:183~186
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