Associations of MMP-2 21306 C/T and MMP-9 21562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis

Meng Han; Qingfeng Yang; Kai Feng; Rongping Li; Jia Ren; Liguang Wei

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자료유형: 학술저널

저자정보: Meng Han (The First Hospital of Qinhuangdao) Qingfeng Yang (The First Hospital of Qinhuangdao) Kai Feng (The First Hospital of Qinhuangdao) Rongping Li (The First Hospital of Qinhuangdao) Jia Ren (The First Hospital of Qinhuangdao) Liguang Wei (The First Hospital of Qinhuangdao)

저널정보: 한국유전학회 Genes & Genomics Genes & Genomics Vol.39 No.3

발행연도: 2017.1

수록면: 331 - 340 (10page)

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The meta-analysis aims to investigate association between two matrix metalloproteinases (MMPs) polymorphisms (MMP-2 -1306 C/T and MMP-9 -1562 C/T) and breast cancer risk. Eligible studies were retrieved from relevant databases, based on predefined criteria. Quality assessment was evaluated by Newcastle–Ottawa Scale. Odds ratio (OR) with its 95% confidence interval (CI) was selected as the effect size for the meta-analysis. As a result, 13 studies were included. MMP-2 -1306 C/T polymorphism was not significantly associated with breast cancer risk under all genetic models (P[0.05). However, subgroup analysis stratified by ethnicity showed a significant association between MMP-2 -1306 C/T polymorphism and reduced breast cancer risk in Asian populations under allelic model (OR 0.60, 95% CI 0.39–0.90, P = 0.02) and dominant model (OR 0.55, 95% CI 0.34–0.89, P = 0.02). MMP-9 -1562 C/T polymorphism was significantly related to increased breast cancer risk under allelic model (OR 1.50, 95% CI 1.06–2.12, P = 0.02), additive model (OR 1.45, 95% CI 1.02–2.05, P = 0.04) and recessive model (OR 1.54, 95% CI 1.13–2.12, OR 0.007). A significant association between MMP-9 -1562 C/T polymorphism and increased breast cancer risk in Caucasian was detected under most of the genetic models (P\0.05). MMP-2 -1306 C/T polymorphism might be significantly associated with reduced breast cancer risk in Asian, while MMP-9 -1562 C/T might be closely related to increased breast cancer risk, especially in Caucasian.

참고문헌 (33)

참고문헌 신청

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