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논문 기본 정보

자료유형
학술저널
저자정보
Guanglin He (Sichuan University) Xing Zou (Chongqing Medical University) Xu Chen (The First People’s Hospital of Liangshan Yi Autonomous Prefecture) Renkuan Tang (Chongqing Medical University) Jing Yan (Sichuan University)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.39 No.7
발행연도
2017.1
수록면
747 - 758 (12page)

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The association between five single nucleotide polymorphisms (SNPs) in brain-derived neurotrophic factor (BDNF) gene (rs6265, rs10767664, rs12273539, rs962369 and rs11030101) and allergic inflammatory disease susceptibility has been extensively reported, while the conclusions were inconclusive. The present study was designed to qualitatively and quantitatively evaluate the relationship between the BDNF polymorphisms and allergic disease risks. A comprehensive literature search of the shared public electronic databases was conducted before September 1, 2016. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using review manager 5.3. Eleven eligible studies (a total of 5217, 6432, 6432, 6432, 4216 subjects focused on rs6265, rs10767664, rs12273539, rs962369 and rs11030101, respectively) were finally contained. Significant genetic association of rs6265 variant and susceptibility of allergic inflammation was observed under allele contrast, recessive and over-dominant model in the overall analysis. Besides, stratified analysis by ethnicity found that the close relationship between rs6265 polymorphism and increased allergic disease risk of Caucasian was observed under recessive and over-dominant model, as well as under allele contrast, recessive, homozygous and over-dominant model in the Asian. Additionally, subgroup analysis based on the disease types showed the obvious relation of rs6265 and asthma risk in several hereditary model. Moreover, strong association between rs10767664 polymorphism and extraordinary risk of allergic disease was also detected in four genetic models. However, no association was discovered with rs962369, rs12273539 and rs11030101. The present meta-analysis suggested that the SNPs (rs10767664 and rs6265) in the BDNF gene is potentially associated with increased allergic disease susceptibility.

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참고문헌 (32)

참고문헌 신청
Andiappan AK / 2011 / Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore / Cytokine 56:218~223 google schola Arshad SH / 2005 / Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age / Chest 127:502~508 google schola Bibel M / 2000 / Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system / Genes Dev 14:2919~2937 google schola Bousquet J / 2008 / Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / Allergy 63(Suppl 86):8~160 google schola Braun A / 1999 / Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma? / Int Arch Allergy Immunol 118:163~165 google schola

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