PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism

Junfeng Yang; Wei Li; Zhuorui Zhang; Jie Shen; Ningnan Zhang; Min Yang; Maolin Yang; Yanhong Yu

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자료유형: 학술저널

저자정보: Junfeng Yang (First People’s Hospital of Yunnan Province) Wei Li (First People’s Hospital of Yunnan Province) Zhuorui Zhang (First People’s Hospital of Yunnan Province) Jie Shen (First People’s Hospital of Yunnan Province) Ningnan Zhang (First People’s Hospital of Yunnan Province) Min Yang (First People’s Hospital of Yunnan Province) Maolin Yang (First People’s Hospital of Yunnan Province) Yanhong Yu (First People’s Hospital of Yunnan Province)

저널정보: 한국유전학회 Genes & Genomics Genes & Genomics Vol.40 No.5

발행연도: 2018.1

수록면: 531 - 541 (11page)

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The aim of this study is to make a comparative evaluation on association of PSCArs2294008 C/T polymorphism with the risk of bladder cancer in Bai, Dai, and Han people in China. A potential mechanism of the T allele risk was also investigated. T allele increased the occurring risk of bladder cancer in Han (OR 1.34; 95% CI 1.17–1.69), Dai, (OR 1.33; 95% CI 1.12–1.70), and Bai (OR 1.14; 95% CI 1.08–1.57) people. T genotype was also observed to associate with invasive bladder cancer in all the three populations (Bai, OR 1.15, 95% CI 1.07–1.87; Dai, OR 1.17, 95% CI 1.05–2.23; Han, OR 1.22, 95% CI 1.10–2.09). PSCA m-RNA levels in T genotype bladder cancer tissues were significantly lower than those in C genotype. An enhancement of PSCA m-RNA level by over-expressing C or T genotype in bladder cancer cells both decreased the cell proliferation and migration, but not affected cell cycle. The increased cell apoptasis due to the over-expression of the two variants was observed. Those change of cell proliferation, migration, and apoptasis was more remarkable in over-expressed C genotype cells than those in over-expressed T genotype. T genotype was genetically high risk to the occurrence of bladder cancer. The decreased PSCA m-RNA levels were involved in the progress of bladder cancer. T allele takes more responsibility for PSCA m-RNA down-regulation to promote cell proliferation and migration and hinder cell apoptasis, thus leading to a higher risk.

참고문헌 (29)

참고문헌 신청

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Chandra V / 2016 / Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) gene polymorphism in modulating cancer risk in Asian population / Genes 7:1065~1075

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Elsamman E / 2006 / Prostate stem cell antigen predicts tumour recurrence in superficial transitional cell carcinoma of the urinary bladder / BJU Int 97:1202~1207

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