지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 54 - 65 (12page)
이용수
초록· 키워드
오류제보하기
Although cancer/testis antigen DDX53 confers anti-cancer drug-resistance, the effect of DDX53 on cancer stem cell-like properties and autophagy remains unknown. MDA-MB-231 (CD133+) cells showed higher expression of DDX53, SOX-2, NANOG and MDR1 than MDA-MB-231 (CD133-). DDX53 increased in vitro self-renewal activity of MCF-7 while decreasing expression of DDX53 by siRNA lowered in vitro self-renewal activity of MDA-MB-231. DDX53 showed an interaction with EGFR and binding to the promoter sequences of EGFR. DDX53 induced resistance to anti-cancer drugs in MCF-7 cells while decreased expression of DDX53 by siRNA increased the sensitivity of MDA-MB-231 to anti-cancer drugs. Negative regulators of DDX53, such as miR-200b and miR-217, increased the sensitivity of MDA-MB-231 to anti-cancer drugs. MDA-MB-231 showed higher expression of autophagy marker proteins such as ATG-5, pBeclin1Ser15 and LC-3I/II compared with MCF-7. DDX53 regulated the expression of mark-er proteins of autophagy in MCF-7 and MDA-MB-231 cells. miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins. Chromatin immunoprecipitation assays showed the direct regulation of ATG-5. The decreased expression of ATG-5 by siRNA increased the sensitivity to anti-cancer drugs in MDA-MB-231 cells. In conclusion, DDX53 promotes stem cell-like properties, autophagy, and confers resistance to anti-cancer drugs in breast cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Ahmad, A. / 2013 / Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs / J. Hematol. Oncol. 6:77
Chen, H. / 2013 / CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival / PLoS One 8:e56878
Chen, Y. / 2016 / Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia / Autophagy 12:1029~1046
Chien, C. S. / 2015 / Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State / Cancer Res. 75:2553~2565
Cho, B. / 2002 / Identification and characterization of a novel cancer/testis antigen gene CAGE / Biochem. Biophys. Res. Commun. 292:715~726
Chen, H. / 2013 / CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival / PLoS One 8:e56878
Chen, Y. / 2016 / Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia / Autophagy 12:1029~1046
Chien, C. S. / 2015 / Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State / Cancer Res. 75:2553~2565
Cho, B. / 2002 / Identification and characterization of a novel cancer/testis antigen gene CAGE / Biochem. Biophys. Res. Commun. 292:715~726
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2
Molecules and Cells
2017 .05
-
Autophagy and Oral Cancer
생명과학회지
2017 .08
-
miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs
Molecules and Cells
2016 .04
-
miR-335 Targets SIAH2 and Confers Sensitivity to Anti-Cancer Drugs by Increasing the Expression of HDAC3
Molecules and Cells
2015 .06
-
인간유방암 MDA-MB-231 세포에서 청국장추출물에 의한 TNFα 발현억제
미생물학회지
2016 .09
-
Novel miR-1958 Promotes Mycobacterium tuberculosis Survival in RAW264.7 Cells by Inhibiting Autophagy Via Atg5
Journal of Microbiology and Biotechnology
2019 .01
-
Overview of the Minireviews on Autophagy
Molecules and Cells
2018 .01
-
Corosolic acid의 유방암세포 증식 및 전이에 미치는 영향
Journal of Nutrition and Health
2020 .04
-
Identification of a Bacillus thuringiensis Surface Layer Protein with Cytotoxic Activity against MDA-MB-231 Breast Cancer Cells
Journal of Microbiology and Biotechnology
2017 .01
-
Loquat (Eriobotrya japonica) leaf extract inhibits the growth of MDA-MB-231 tumors in nude mouse xenografts and invasion of MDA-MB-231 cells
Nutrition Research and Practice
2016 .04
-
Loquat (Eriobotrya japonica) leaf extract inhibits the growth of MDA-MB-231 tumors in nude mouse xenografts and invasion of MDA-MB-231 cells
Nutrition Research and Practice
2016 .04
-
Improved Anti-Cancer Effect of Curcumin on Breast Cancer Cells by Increasing the Activity of Natural Killer Cells
Journal of Microbiology and Biotechnology
2018 .01
-
Biological Roles of Alternative Autophagy
Molecules and Cells
2018 .01
-
Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
한국미생물·생명공학회지
2019 .01
-
The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Genes & Genomics
2021 .01
-
3D Wave of Fermented Soybean Extracts Suppress Proliferation of Human Breast Cancer MDA-MB-231 Cells
한국미생물학회 학술대회논문집
2016 .04
-
The MicroRNA-551a/MEF2C Axis Regulates the Survival and Sphere Formation of Cancer Cells in Response to 5-Fluorouracil
Molecules and Cells
2019 .01
-
The autophagy research in electron microscopy
한국현미경학회지
2019 .01
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
-
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice
Nutrition Research and Practice
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0