지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.5
- 수록면
- 346 - 354 (9page)
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초록· 키워드
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Long interspersed nuclear element-1 (LINE-1) is a retrotransposon that contains a CpG island in its 5?-untranslated region. The CpG island of LINE-1 is often heavily methylated in normal somatic cells, which is associated with poor prognosis in various cancers. DNA methylation can differ between formalin-fixed paraffin-embedded (FFPE) and frozen tissues. Therefore, this study aimed to compare the LINE-1 methylation status between the two tissue-storage conditions in gastric cancer (GC) clinical samples and to evaluate whether LINE-1 can be used as an independent prognostic marker for each tissue-storage type. We analyzed four CpG sites of LINE-1 and examined the methylation levels at these sites in 25 FFPE and 41 frozen GC tissues by quantitative bisulfite pyrosequencing. The LINE-1 methylation status was significantly different between the FFPE and frozen GC tissues (p < 0.001). We further analyzed the clinicopathological features in the two groups separately. In the frozen GC tissues, LINE-1 was significantly hypomethylated in GC tissues compared to their corres-ponding normal gastric mucosa tissues (p < 0.001), and its methylation status was associated with gender, differentiation state, and lymphatic and venous invasion of GC. In the FFPE GC tissues, the methylation levels of LINE-1 differed according to tumor location and venous invasion of GC. In conclusion, LINE-1 can be used as a useful methylation marker for venous invasion in both FFPE and frozen tumor tissues of GC.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Aparicio, A. / 2009 / LINE-1methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors / Epigenetics 4:176~184
Baba, Y. / 2014 / Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer / Surg. Today 44:1807~1816
Bae, J. M. / 2012 / ALU and LINE-1hypomethylations in multistep gastric carcinogenesis and their prognostic implications / Int. J. Cancer 131:1323~1331
Barchitta, M. / 2014 / LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis / PLoS One 9:e109478
Cash, H. L. / 2012 / LINE-1hypomethylation is associated with bladder cancer risk among nonsmoking Chinese / Int. J. Cancer 130:1151~1159
Baba, Y. / 2014 / Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer / Surg. Today 44:1807~1816
Bae, J. M. / 2012 / ALU and LINE-1hypomethylations in multistep gastric carcinogenesis and their prognostic implications / Int. J. Cancer 131:1323~1331
Barchitta, M. / 2014 / LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis / PLoS One 9:e109478
Cash, H. L. / 2012 / LINE-1hypomethylation is associated with bladder cancer risk among nonsmoking Chinese / Int. J. Cancer 130:1151~1159
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