지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 229 - 241 (13page)
이용수
초록· 키워드
오류제보하기
We have previously reported the role of miR-326-HDAC3 loop in anti-cancer drug-resistance. CAGE, a cancer/testis antigen, regulates the response to anti-cancer drug-resistance by forming a negative feedback loop with miR-200b. Studies investigating the rela-tionship between CAGE and HDAC3 revealed that HDAC3 negatively regulated the expression of CAGE. ChIP assays demonstrated the binding of HDAC3 to the promoter sequences of CAGE. However, CAGE did not affect the expression of HDAC3. We also found that EGFR signaling regulated the expressions of HDAC3 and CAGE. Anti-cancer drug-resistant cancer cell lines show an increased expression of pEGFRY845. HDAC3 was found to negatively regulate the expression of pEGFRY845. CAGE showed an interaction and co-localization with EGFR. It was seen that miR-326, a negative regulator of HDAC3, regulated the expression of CAGE, pEGFRY845, and the interaction between CAGE and EGFR. miR-326 inhibitor induced the binding of HDAC3 to the promoter sequences in anti-cancer drug-resistant Malme3MR cells, decreasing the tumorigenic potential of Malme3MR cells in a manner associated with its effect on the expression of HDAC3, CAGE and pEGFRY845. The down-regulation of HDAC3 enhanced the tumorigenic, angiogenic and invasion potential of the anti-cancer drug-sensitive Malme3M cells in CAGE-dependent manner. Studies re-vealed that PKC? was responsible for the increased ex-pression of pEGFRY845 and CAGE in Malme3MR cells. CAGE showed an interaction with PKC? in Malme3MR cells. Our results show that HDAC3-CAGE axis can be employed as a target for overcoming resistance to EGFR inhibitors.
목차
등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Abera, M. B. / 2015 / Protein kinase Cα mediates erlotinib resistance in lung cancer cells / Mol. Pharmacol 87:832~841
Barter, M. J. / 2010 / HDACmediated control of ERK-and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes / Matrix Biol 29:602~612
Bhaskara, S. / 2010 / Hdac3 is essential for the maintenance of chromatin structure and genome stability / Cancer Cell 18:436~447
Boyer, A. P. / 2013 / Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers / Mol. Cell. Proteomics 12:180~193
Brodie, S. A. / 2014 / Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1and serve as promising targets for chemoprevention of lung cancer / Cancer Prev. Res. (Phila) 7:351~361
Barter, M. J. / 2010 / HDACmediated control of ERK-and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes / Matrix Biol 29:602~612
Bhaskara, S. / 2010 / Hdac3 is essential for the maintenance of chromatin structure and genome stability / Cancer Cell 18:436~447
Boyer, A. P. / 2013 / Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers / Mol. Cell. Proteomics 12:180~193
Brodie, S. A. / 2014 / Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1and serve as promising targets for chemoprevention of lung cancer / Cancer Prev. Res. (Phila) 7:351~361
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
miR-335 Targets SIAH2 and Confers Sensitivity to Anti-Cancer Drugs by Increasing the Expression of HDAC3
Molecules and Cells
2015 .06
-
Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer
Genes & Genomics
2024 .07
-
miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs
Molecules and Cells
2016 .04
-
GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis
Genes & Genomics
2021 .08
-
HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
Molecules and Cells
2015 .04
-
HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription
Molecules and Cells
2017 .09
-
Rpd3L HDAC Links H3K4me3 to Transcriptional Repression Memory
한국미생물학회 학술대회논문집
2018 .04
-
Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons
Molecules and Cells
2017 .07
-
Transforming Growth Factor β Inhibits MUC5AC Expression by Smad3/HDAC2 Complex Formation and NF-κB Deacetylation at K310 in NCI-H292 Cells
Molecules and Cells
2021 .01
-
Effect of Histone Deacetylase Inhibitors on Differentiation of Human Bone Marrow-derived Stem Cells Into Neuron-like Cells
조선자연과학논문집
2019 .01
-
Characterization of HDAC9 isoforms in brain microvessel bEnd.3 cells upon oxygen and glucose deprivation–reperfusion injury
Genes & Genomics
2015 .01
-
Potassium Acetate Blocks Clostridium difficile Toxin A-Induced Microtubule Disassembly by Directly Inhibiting Histone Deacetylase 6, Thereby Ameliorating Inflammatory Responses in the Gut
Journal of Microbiology and Biotechnology
2016 .01
-
항암제 tubastatin A에 의한 생쥐 미성숙 난모세포의 성장과 발달에 미치는 효과
생명과학회지
2019 .01
-
The MicroRNA-551a/MEF2C Axis Regulates the Survival and Sphere Formation of Cancer Cells in Response to 5-Fluorouracil
Molecules and Cells
2019 .01
-
Insulin-like Growth Factor-I Modulates BDNF Expression by Inhibition of Histone Deacetylase in C2C12 Skeletal Muscle Cells
생명과학회지
2017 .08
-
Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer
Journal of Microbiology and Biotechnology
2021 .01
-
DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy
Molecules and Cells
2017 .01
-
난소 절제 쥐의 골격근에서 갈근 및 지황 섭취와 운동이 후성 유전적 변화에 미치는 영향
생명과학회지
2015 .11
-
Nickel foam caging Ag-Au bimetallic nanostructure as a SERS substrate
한국분석과학회 학술대회
2018 .05
-
Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders
Molecules and Cells
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0