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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.5
- 수록면
- 367 - 374 (8page)
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Since the RNA world hypothesis was proposed, a large number of regulatory noncoding RNAs (ncRNAs) have been identified in many species, ranging from microorganisms to mammals. During the characterization of these newly discovered RNAs, RNAs having both coding and noncoding functions were discovered, and these were considered bifunctional RNAs. The recent use of computational and high-throughput experimental approaches has revealed increasing evidence of various sources of bifunctional RNAs, such as protein-coding mRNAs with a noncoding isoform and long ncRNAs bearing a small open reading frame. Therefore, the genomic diversity of Janus-faced RNA molecules that have dual characteristics of coding and noncoding indicates that the functional roles of RNAs have to be revisited in cells on a genome-wide scale. Such studies would allow us to further understand the complex gene-regulatory network in cells. In this review, we discuss three major genomic sources of bifunctional RNAs and present a handful of examples of bifunctional RNA along with their functional roles.
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참고문헌 (60)
참고문헌 신청
Anderson, D. M. / 2015 / A micropeptide encoded by a putative long noncoding RNA regulates muscle performance / Cell 160:595~606
Andrews, S. J. / 2014 / Emerging evidence for functional peptides encoded by short open reading frames / Nat. Rev. Genet 15:193~204
Aspden, J. L. / 2014 / Extensive translation of small open reading frames revealed by Poly-Ribo-Seq / Elife 3:03528
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Beadle, G. W. / 1941 / Genetic Control of Biochemical Reactions in Neurospora / Proc. Natl. Acad. Sci. USA 27:499~506
Andrews, S. J. / 2014 / Emerging evidence for functional peptides encoded by short open reading frames / Nat. Rev. Genet 15:193~204
Aspden, J. L. / 2014 / Extensive translation of small open reading frames revealed by Poly-Ribo-Seq / Elife 3:03528
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Beadle, G. W. / 1941 / Genetic Control of Biochemical Reactions in Neurospora / Proc. Natl. Acad. Sci. USA 27:499~506
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