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논문 기본 정보
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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제6호
- 발행연도
- 2015.1
- 수록면
- 946 - 950 (5page)
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Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drugsensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 μg/ml) as well as drugresistant strains (MIC, 6.25 to 12.5 μg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
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참고문헌 (18)
참고문헌 신청
Atroshi F / 1998 / Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins / Pharmacol. Res 38 : 289
Caleffi-Ferracioli KR / 2013 / Fast detection of drug interaction in Mycobacterium tuberculosis by a checkerboard resazurin method / Tuberculosis (Edinb.) 93 : 660 ~ 663
Changsen C / 2003 / Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter / Antimicr
Chen FC / 2014 / Pros and cons of the tuberculosis drugome approach - an empirical analysis / PLoS One 9 : e100829 ~
Christophe T / 2009 / High content screening identifies decaprenyl-phosphoribose 2’ epimerase as a target for intracellular antimycobacterial inhibitors / PLoS Pathog 5 : e1
Caleffi-Ferracioli KR / 2013 / Fast detection of drug interaction in Mycobacterium tuberculosis by a checkerboard resazurin method / Tuberculosis (Edinb.) 93 : 660 ~ 663
Changsen C / 2003 / Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter / Antimicr
Chen FC / 2014 / Pros and cons of the tuberculosis drugome approach - an empirical analysis / PLoS One 9 : e100829 ~
Christophe T / 2009 / High content screening identifies decaprenyl-phosphoribose 2’ epimerase as a target for intracellular antimycobacterial inhibitors / PLoS Pathog 5 : e1
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