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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제9호
- 발행연도
- 2017.1
- 수록면
- 1,549 - 1,558 (10page)
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Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a prevalent infectious disease worldwide owing to the limitations of current TB therapeutic regimens.
Recent work on novel TB treatment strategies has suggested that directly targeting host factors may be beneficial for TB treatment. Such strategies, termed host-directed therapeutics (HDTs), focus on host-pathogen interactions. HDTs may be more effective than the currently approved TB drugs, which are limited by the long durations of treatment needed and the emergence of drug-resistant strains. Targets of HDTs include host factors such as cytokines, immune checkpoints, immune cell functions, and essential enzyme activities. This review article discusses examples of potentially promising HDTs and introduces novel approaches for their development.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Arbex MA / 2010 / Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs / J. Bras. Pneumol 36 : 626 ~ 640
Arbex MA / 2010 / Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs / J. Bras. Pneumol 36 : 641 ~ 656
Aubry A / 2004 / Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity / Antimicrob. Agents Chemother 48 :
Baulard AR / 2000 / Activati
Caceres NE / 1997 / Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis / J. Bacteriol 179 : 5046 ~ 5055
Arbex MA / 2010 / Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs / J. Bras. Pneumol 36 : 641 ~ 656
Aubry A / 2004 / Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity / Antimicrob. Agents Chemother 48 :
Baulard AR / 2000 / Activati
Caceres NE / 1997 / Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis / J. Bacteriol 179 : 5046 ~ 5055
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