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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 67 - 67 (1page)
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The most accepted targeted-agent for treating ER-alpha positive breast cancer is Tamoxifen. Yet over 30% of patients gain resistance. Recently, lipid metabolism has been rising as a new mode of anticancer drug resistance. In order for a rapid growth, cancer cells show a strong avidity for lipids which they obtain by de novo lipogenesis or increasing the uptake of exogenous lipids. Lipid metabolism may confer anticancer drug resistance, but little is known about its association with endocrine resistance. Thus, we aimed to investigate specific alterations in lipid metabolic pathways in the context of tamoxifen resistance. First, according to microarray data analysis, a set of genes responsible for fatty acid uptake and activation were elevated in MCF7/TAMR and T47D/TR cells. Also, genes involved in ketogenesis were overexpressed in resistant ce^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10557948');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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