지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 848 - 855 (8page)
이용수
초록· 키워드
오류제보하기
Cells assemble stress granules (SGs) to protect their RNAs from exposure to harmful chemical reactions induced by environmental stress. These SGs release RNAs, which resume translation once the stress is relieved. During stem cell differentiation, gene expression is altered to allow cells to adopt various functional and morphological features necessary to differentiate. This process induces stress within a cell, and cells that cannot overcome this stress die. Here, we investigated the role of SGs in the progression of stem cell differentiation. SGs aggregated during the neuronal differentiation of human bone marrow-mesenchymal stem cells, and not in cell lines that could not undergo differentiation. SGs were observed between one and three hours post-induction; RNA translation was restrained at the same time. Immediately after disassembly of SGs, the expression of the neuronal marker neurofilament-M (NFM) gradually increased. Assembled SGs that persisted in cells were exposed to salubrinal, which inhibited the dephosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2α), and in eIF2α/S51D mutant cells. When eIF2α/S51A mutant cells differentiated, SGs were not assembled. In all experiments, the disruption of SGs was accompanied by delayed NF-M expression and the number of neuronally differentiated cells was decreased. Decreased differentiation was accompanied by decreased cell viability, indicating the necessity of SGs for preventing cell death during neuronal differentiation. Collectively, these results demonstrate the essential role of SGs during the neuronal differentiation of stem cells.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Anderson, P. / 2006 / RNA granules / J. Cell Biol 172:803~808
Anderson, P. / 2008 / Stress granules : the Tao of RNA triage / Trends Biochem. Sci 33:141~150
Anderson, P. / 2009 / RNA granules : post-transcriptional and epigenetic modulators of gene expression / Nat. Rev. Mol. Cell Biol 10:430~436
Aulas, A. / 2017 / Stress-specific differences in assembly and composition of stress granules and related foci / J. Cell Sci 130:927~937
Black, D. L / 2003 / Mechanisms of alternative pre-messenger RNA splicing / Annu. Rev. Biochem 72:291~336
Anderson, P. / 2008 / Stress granules : the Tao of RNA triage / Trends Biochem. Sci 33:141~150
Anderson, P. / 2009 / RNA granules : post-transcriptional and epigenetic modulators of gene expression / Nat. Rev. Mol. Cell Biol 10:430~436
Aulas, A. / 2017 / Stress-specific differences in assembly and composition of stress granules and related foci / J. Cell Sci 130:927~937
Black, D. L / 2003 / Mechanisms of alternative pre-messenger RNA splicing / Annu. Rev. Biochem 72:291~336
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differentiation of mesenchymal stem cells on nanopillar/pit array structures
한국진공학회 학술발표회초록집
2017 .02
-
Characterization of Primary Epithelial Cells Derived from Human Salivary Gland Contributing to in vivo Formation of Acini-like Structures
Molecules and Cells
2018 .06
-
Depletion of PDCD4 Accelerates Stress Granule Assembly Through Sensitization of Stress Response Pathways
조선자연과학논문집
2019 .01
-
Stress Granules Inhibit Coxsackievirus B3-Mediated Cell Death via Reduction of Mitochondrial Reactive Oxygen Species and Viral Extracellular Release
Journal of Microbiology and Biotechnology
2023 .05
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
-
Role of non-thermal atmospheric pressure bio-compatible plasma on human stem cells
한국진공학회 학술발표회초록집
2017 .02
-
Directed Differentiation of Pluripotent Stem Cells by Trascription Factors
Molecules and Cells
2019 .01
-
MicroRNA-126은 난소 종양세포의 줄기세포 전사인자 (Sox2와 Lin28) 발현을 조절한다
대한임상검사과학회지
2015 .01
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells
Genes & Genomics
2021 .01
-
Characterizing Organelles in Live Stem Cells Using Label-Free Optical Diffraction Tomography
Molecules and Cells
2021 .11
-
NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells
Molecules and Cells
2020 .01
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
인간 골수유래-중간엽 줄기세포(hBM-MSCs)에서 PDE4 억제조절을 통한 신경세포 분화 효율 개선
생명과학회지
2016 .12
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
On strongly Gorenstein hereditary rings
대한수학회보
2019 .01
-
Hepatocyte growth factor (HGF) promotes cardiac stem cell differentiation after myocardial infarction by increasing mTOR activation in p27kip haploinsufficient mice
Genes & Genomics
2015 .01
-
Imaging neuronal cell with atomic force microscopy
한국진공학회 학술발표회초록집
2016 .08
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0