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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 417 - 424 (8page)
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초록· 키워드
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This study aimed to explore the effects of brain-derived neurotrophic factor (BDNF), produced by engineered immortalized mesenchymal stem cells (imMSC), on lower urinary tract symptoms (LUTS) in a rat model with neurogenic bladder (NB). Forty-eight Sprague-Dawley (SD) rats were randomly divided into the following groups: Sham control, LUTS, LUTS+imMSC (treated with immortalized MSC), and LUTS+BDNF-eMSC (treated with BDNF-expressing MSC) groups. LUTS was induced by a crush injury to the major pelvic ganglion (MPG). Bladder function was tested under anesthesia, and bladder tissue strips were collected thereafter for contractility test and western blot analysis. Western blot results showed that the expression of both Angiopoietin 1 (Ang 1) and platelet-derived growth factor (PDGF) increased with MSC injection. The effect of treatment with BDNF-eMSC on LUTS was also evaluated, and the results were found to be better than those with imMSC (P＜0.05). BDNF-eMSC prevented fibrosis in the bladder tissue and significantly reduced caspase-3 levels. In conclusion, high expression of BDNF in vivo resulted in recovery of bladder function and contractility, along with the inhibition of apoptosis in a rat model.
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참고문헌 (22)
참고문헌 신청
C. Eveno / 2010 / Sexual and urinary dysfunction after proctectomy for rectal cancer / Journal of Visceral Surgery 147(1):e21~e30
Rizwan Hamid / 2018 / Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury / World Journal of Urology 36(10):1517~1527
Anthony Atala / 2011 / Re: Reconstitution of Experimental Neurogenic Bladder Dysfunction Using Skeletal Muscle-Derived Multipotent Stem Cells / Journal of Urology 185(1):353~353
Thomas M. Fandel / 2012 / Recruitment of Intracavernously Injected Adipose-Derived Stem Cells to the Major Pelvic Ganglion Improves Erectile Function in a Rat Model of Cavernous Nerve Injury / European Urology 61(1):201~210
Min Gong / 2011 / Immortalized mesenchymal stem cells: an alternative to primary mesenchymal stem cells in neuronal differentiation and neuroregeneration associated studies / Journal of Biomedical Science 18(1):87
Rizwan Hamid / 2018 / Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury / World Journal of Urology 36(10):1517~1527
Anthony Atala / 2011 / Re: Reconstitution of Experimental Neurogenic Bladder Dysfunction Using Skeletal Muscle-Derived Multipotent Stem Cells / Journal of Urology 185(1):353~353
Thomas M. Fandel / 2012 / Recruitment of Intracavernously Injected Adipose-Derived Stem Cells to the Major Pelvic Ganglion Improves Erectile Function in a Rat Model of Cavernous Nerve Injury / European Urology 61(1):201~210
Min Gong / 2011 / Immortalized mesenchymal stem cells: an alternative to primary mesenchymal stem cells in neuronal differentiation and neuroregeneration associated studies / Journal of Biomedical Science 18(1):87
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